SAB4200797

Anti-HSP70 antibody produced in rabbit

IgG fraction of antiserum

• Sinonimo/i: Anti-Heat shock 70 kDa protein
• Codice UNSPSC: 12352203
• NACRES: NA.41

Proprietà

• Origine biologica: rabbit
• Livello qualitativo: 200
• Forma dell’anticorpo: IgG fraction of antiserum
• Tipo di anticorpo: primary antibodies
• Clone: polyclonal
• Forma fisica: buffered aqueous solution
• PM: ~70 kDa
• Reattività contro le specie: chicken, rat, canine, human, monkey, mouse, bovine
• tecniche: immunoblotting: 1:250-1:500 using different cell extracts; immunoprecipitation (IP): 10-20 μg/test
• N° accesso UniProt: P0DMV8
• Condizioni di spedizione: dry ice
• Temperatura di conservazione: −20°C
• modifica post-traduzionali bersaglio: unmodified
• Informazioni sul gene: human ... HSPA1A(3303)

Descrizione

Descrizione generale

Heat Shock Proteins 70 (HSP70), also known as HSPA1A (heat shock protein family A (Hsp70) member 1A) or HSPA1B (heat shock protein family A (Hsp70) member 1B) is encoded by the gene mapped to human chromosome 6p21.3. xHSP70 is a highly conserved protein family with four members such as the constitutive (or cognate) HSP73, the stress-inducible HSP72, the glucose regulated proteins (grp)78 and grp75. During heat shock, HSP70s concentrate in the cell nuclei and return to the cytoplasm when the shock is removed.

Immunogeno

Synthetic peptide from the internal region of human HSP70 protein, conjugated to KLH

Applicazioni

The antibody has been used in various immunochemical techniques including immunoblotting (∼70 kDa) and immunoprecipitation.Detection of the HSP70 band by Immunoblotting is specifically inhibited by the immunogen.

Azioni biochim/fisiol

Heat Shock Proteins 70 (HSP70) plays a key role in stress response, including heat stress, in every organism in which the proteins have been examined. These proteins also facilitates a wide range of folding processes, including the folding and assembly of newly synthesized proteins, refolding of misfolded and aggregated proteins, membrane translocation of organellar and secretory proteins, and control of the activity of regulatory proteins. In addition, HSP70 also play a cytoprotective role in neurodegenerative diseases such as Alzheimer′s, Parkinson′s, Huntington′s, ALS and others. Unregulated expression of HSP70s leads to the development of several types of cancer, such as malignant melanoma and renal cell cancer.

Stato fisico

Supplied as a solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide as a preservative.

Altre note

This product is for R&D use only, not for drug, household, or other uses.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 10 - Combustible liquids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable