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SAB3500252

Sigma-Aldrich

Anti-TIM-1 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Sinonimo/i:

Anti-T cell immunoglobulin and mucin domain containing protein 1

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100 μG
CHF 476.00

CHF 476.00


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Cambia visualizzazione
100 μG
CHF 476.00

About This Item

Codice UNSPSC:
12352203
NACRES:
NA.41

CHF 476.00


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Origine biologica

rabbit

Livello qualitativo

Coniugato

unconjugated

Forma dell’anticorpo

affinity isolated antibody

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Stato

buffered aqueous solution

PM

predicted mol wt 40 kDa

Reattività contro le specie

human, mouse

tecniche

immunofluorescence: suitable
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable

N° accesso NCBI

N° accesso UniProt

Condizioni di spedizione

dry ice

Temperatura di conservazione

−20°C

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... HAVCR1(26762)

Descrizione generale

Hepatitis A virus cellular receptor 1 (HAVCR1) or T-cell immunoglobulin and mucin protein (TIM-1) is a type 1 transmembrane glycoprotein. The protein is found in the apical membrane of cells. It is expressed in the kidney, testis and activated CD4+ T-cells. It possesses a six-cysteine immunoglobulin-like domain, a T/SP rich domain and two N-glycosylation sites. The TIM-1 gene is localized on human chromosome 5q33.2.

Immunogeno

TIM-1 antibody was raised against a 16 amino acid peptide from near the amino terminus of human TIM-1.

Applicazioni

Anti-TIM-1 antibody produced in rabbit has been used in immunofluorescence.

Azioni biochim/fisiol

Hepatitis A virus cellular receptor 1 (HAVCR1) regulates susceptibility to human immunodeficiency virus-1 (HIV-1) infection. It is upregulated in injured kidneys. HAVCR1 inhibits the activation of the Ga12 G-protein by blocking its association to GTP. Polymorphisms in the protein have been associated with immune dysfunction.

Caratteristiche e vantaggi

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Linkage

The action of this antibody can be blocked using blocking peptide SBP3500252.

Stato fisico

Supplied in PBS with 0.02% sodium azide.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable


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Lei Tian et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 41(2), 769-783 (2017-02-20)
Kidney injury molecule-1 (KIM-1) is highly expressed in renal tubular cells after injury and is usually regarded as an early biomarker of acute kidney injury(AKI). The aim of this study was to determine the role of KIM-1 in the development
Kidney injury molecule-1 (KIM-1) mediates renal epithelial cell repair via ERK MAPK signaling pathway.
Zhang Z and Cai CX
Molecular and Cellular Biochemistry, 109-116 (2016)
Associations Between TIM1 Polymorphisms and Dilated Cardiomyopathy in a Han Chinese Population.
Xie X
International Heart Journal, 57(6), 742-746 (2016)
Kidney Injury Molecule-1 and Cardiovascular Diseases: From Basic Science to Clinical Practice.
Medic B
BioMed Research International, 854070-854070 (2015)
Kidney Injury Molecule-1 is Elevated in Nephropathy and Mediates Macrophage Activation via the Mapk Signalling Pathway
Tian L
Cellular Physiology and Biochemistry, 41 (2017)

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