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S7809

Sigma-Aldrich

SKF-96365

≥98% (HPLC), solid

Sinonimo/i:

1-[β-(3-(4-Methoxyphenyl)propoxy)-4-methoxyphenethyl]-1H-imidazole hydrochloride, 1-[2-(4-Methoxyphenyl)-2-[3-(4-methoxyphenyl)propoxy]ethyl]imidazole

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5 MG
CHF 205.00

CHF 205.00

Spedizione prevista il15 maggio 2025

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5 MG
CHF 205.00

About This Item

Formula empirica (notazione di Hill):
C22H26N2O3 · HCl
Numero CAS:
130495-35-1
Peso molecolare:
402.91
Numero MDL:
MFCD00236407
Codice UNSPSC:
12352200
ID PubChem:
24278710
NACRES:
NA.77

CHF 205.00

Spedizione prevista il15 maggio 2025

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Livello qualitativo

100

Saggio

≥98% (HPLC)

Stato

solid

Colore

white

Solubilità

DMSO: >20 mg/mL
H2O: >20 mg/mL

Stringa SMILE

Cl.COc1ccc(CCCOC(Cn2ccnc2)c3ccc(OC)cc3)cc1

InChI

1S/C22H26N2O3.ClH/c1-25-20-9-5-18(6-10-20)4-3-15-27-22(16-24-14-13-23-17-24)19-7-11-21(26-2)12-8-19;/h5-14,17,22H,3-4,15-16H2,1-2H3;1H
FWLPKVQUECFKSW-UHFFFAOYSA-N

Applicazioni

SKF-96365 has been used as :
  • a nonselective transient receptor potential 6 (TRPC6) blocker in human podocytes[1]
  • an antagonist of store-operated Ca2+ influx in neurons[2]
  • an inhibitor for transient receptor potential 3 (TRPC3) in mice[3]

Azioni biochim/fisiol

SKF-96365 with an alkylated imidazole ring is a selective inhibitor of receptor-mediated Ca2+ entry and voltage-gated Ca2+ entry .[4] SKF-96365 mediated depolarization of smooth cardiac muscle membrane and had no impact on the acetylcholine (ACh)-induced depolarization.[5] It is an inhibitor for SOCE (store-operated calcium entry). It also inhibits Homer1 protein expression.[6] SKF-96365 elicits protective functionality in 1-methyl-4-phenylpyridinium(MPP) mediated cytotoxicity.[6]

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Gloves

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Certificati d'analisi (COA)

Lot/Batch Number
0000386438
0000361572
0000361572
0000386438
0000064236

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The transient receptor potential channel antagonist SKF96365 is a potent blocker of low-voltage-activated T-type calcium channels
Singh A, et al.
British Journal of Pharmacology, 160(6), 1464-1475 (2010)
J E Merritt et al.
The Biochemical journal, 271(2), 515-522 (1990-10-15)
A novel inhibitor of receptor-mediated calcium entry (RMCE) is described. SK&F 96365 (1-(beta-[3-(4-methoxy-phenyl)propoxy]-4-methoxyphenethyl)-1H- imidazole hydrochloride) is structurally distinct from the known 'calcium antagonists' and shows selectivity in blocking RMCE compared with receptor-mediated internal Ca2+ release. Human platelets, neutrophils and endothelial
Protective effects of SKF-96365, a non-specific inhibitor of SOCE, against MPP+-induced cytotoxicity in PC12 cells: potential role of Homer1
Chen T, et al.
PLoS ONE, 8(1), e55601-e55601 (2013)
Arnaud Guilbert et al.
BMC cancer, 8, 125-125 (2008-05-03)
TRP channels have been shown to be involved in tumour generation and malignant growth. However, the expression of these channels in breast cancer remains unclear. Here we studied the expression and function of endogenous TRPC6 channels in a breast cancer
Effects of inhibitors of nonselective cation channels on the acetylcholine-induced depolarization of circular smooth muscle from the guinea-pig stomach antrum
Hotta A, et al.
Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi, 41(6), 313-327 (2005)
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