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Merck
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S3065

Sigma-Aldrich

SC 19220

≥98% (HPLC), solid

Sinonimo/i:

2-Acetylhydrazide 10(11H)-carboxylic acid, 8-Chloro-dibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid

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About This Item

Formula empirica (notazione di Hill):
C16H14N3O3Cl
Numero CAS:
19395-87-0
Peso molecolare:
331.75
Numero MDL:
MFCD02259329
Codice UNSPSC:
12352200
ID PubChem:
24278701
NACRES:
NA.77

Saggio

≥98% (HPLC)

Forma fisica

solid

Colore

white

Punto di fusione

190-191 °C (lit.)

Solubilità

DMSO: soluble 10 mg/mL
H2O: insoluble

Stringa SMILE

CC(=O)NNC(=O)N1Cc2ccccc2Oc3ccc(Cl)cc13

InChI

1S/C16H14ClN3O3/c1-10(21)18-19-16(22)20-9-11-4-2-3-5-14(11)23-15-7-6-12(17)8-13(15)20/h2-8H,9H2,1H3,(H,18,21)(H,19,22)
KNURFLJTOUGOOQ-UHFFFAOYSA-N

Informazioni sul gene

human ... PTGER1(5731)
rat ... Ptger1(25637)

Categorie correlate

Applicazioni

SC 19220 was used to study the role of prostaglandin E2 in oxygen-glucose deprivation-induced neurotoxicity and preconditioning-induced neuroprotection in rat cortical cultures.

Azioni biochim/fisiol

SC 19220 is a competitive antagonist of prostaglandin E receptors. It competes with PGE2 in regulating vesicourethral motility and increases the bladder capacity of rats. It inhibits the contraction of smooth muscles in response to prostaglandins E2 and F2α. SC 19220 also inhibits the formation of osteoclasts induced by vitamin D3, parathyroid hormone, IL-11 and IL-6.
EP1 Prostanoid receptor antagonist

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

Certificati d'analisi (COA)

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K Oka et al.
The American journal of physiology, 275(6 Pt 2), R1762-R1765 (1998-12-09)
We have previously reported that central injection of PGE2 induces hyperthermia through its actions on EP1 receptors in rats. Because the increase in local synthesis of PGE2 is assumed to be a necessary process in a fever caused by central
L Walch et al.
British journal of pharmacology, 134(8), 1671-1678 (2001-12-12)
1. To characterize the prostanoid receptors (TP, FP, EP(1) and/or EP(3)) involved in the vasoconstriction of human pulmonary veins, isolated venous preparations were challenged with different prostanoid-receptor agonists in the absence or presence of selective antagonists. 2. The stable thromboxane
S Santangelo et al.
The Journal of trauma, 48(5), 826-830 (2000-05-24)
Although prostaglandin E2 (PGE2) has been shown to be immunosuppressive, its role in the development of specific bone marrow myeloid lineages after thermal injury and sepsis has yet to be elucidated. The purpose of this study was to demonstrate that
J B Farmer et al.
British journal of pharmacology, 52(4), 559-565 (1974-12-01)
1 The effects of the prostaglandin synthetase inhibitor, indomethacin and the prostaglandin antagonist SC-19220 (1-acetyl-2-[8-chloro-10,11-dihydrodibenz (b,f) (1,4)oxazepine-10-carbonyl] hydrazine), were examined on the tone of the guinea-pig isolated tracheal preparation and on the responses of the preparation to prostaglandin F(2alpha), arachidonic
K Fushimi et al.
Osteoarthritis and cartilage, 12(11), 895-903 (2004-10-27)
Calpains are known as Ca(2+)-dependent intracellular neutral cysteine proteases. However, m-calpain is detected in synovial fluid of arthritic joints and is shown to possess the proteoglycanase activity in vitro. The mechanism of m-calpain release into the extracellular spaces during arthritis
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