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S3007

Sigma-Aldrich

Sodium salicylate

ReagentPlus®, ≥99.5% (titration)

Sinonimo/i:

2-Hydroxybenzoic acid sodium salt, Salicylic acid sodium salt, Sodium 2-hydroxybenzoate

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500 G
CHF 130.00
1 KG
CHF 207.00
5 KG
CHF 763.00

CHF 130.00

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Cambia visualizzazione
500 G
CHF 130.00
1 KG
CHF 207.00
5 KG
CHF 763.00

About This Item

Formula condensata:
HOC6H4COONa
Numero CAS:
54-21-7
Peso molecolare:
160.10
Beilstein:
3732792
Numero CE:
200-198-0
Numero MDL:
MFCD00002440
Codice UNSPSC:
12352302
ID PubChem:
24899540
NACRES:
NA.25
Saggio:
≥99.5% (titration)
Stato:
crystalline
Solubilità:
water: 575.7 g/L at 25 °C (77 °F)

CHF 130.00

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Livello qualitativo

200

Nome Commerciale

ReagentPlus®

Saggio

≥99.5% (titration)

Stato

crystalline

Colore

white

Intervallo di pH utile

6.85 (26.3 °C)

Punto di fusione

>300 °C (lit.)

Solubilità

water: 575.7 g/L at 25 °C (77 °F)

Stringa SMILE

[Na+].Oc1ccccc1C([O-])=O

InChI

1S/C7H6O3.Na/c8-6-4-2-1-3-5(6)7(9)10;/h1-4,8H,(H,9,10);/q;+1/p-1
ABBQHOQBGMUPJH-UHFFFAOYSA-M

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Categorie correlate

Descrizione generale

Sodium salicylate is the active ingredient in aspirin, commonly used as antipyretic, anti-inflammatory and analgesic drug. Sodium salicylate when taken in large quantities causes temporary hearing loss and tinnitus. Prolonged treatment with sodium salicylate reduces output from cochlea permanently, reduces compound action potential amplitude in vivo and neural degeneration in vitro.[1] Sodium salicylate treatment in lateral amygdala alters tonography and excitability, causing hyperactivity in auditory cortex.[2] Sodium salicylate impairs the expression of cellular-Finkel−Biskis−Jinkins murine osteogenic sarcoma virus (c-fos) and δ-FosB proteins in hippocampus region and affects spatial memory and learning. Sodium salicylate affects neurogenesis in dentate gyrus region of the brain.[3]

Applicazioni

Sodium salicylate has been used:
  • to induce tinnitus, hyperacusis-like behavior in rats and infused directly into amygdala to measure local field potential.[2]
  • to induce and confirm tinnitus by prepulse inhibition behavior (PPI) and its inhibition on learning and memory by Morris water maze test and subsequent gene expression studies in rats.[3]
  • to enhance gamma amino butyric acid (GABA)ergic inhibition and enhance auditory response in the dorsal cortex of the inferior colliculus (ICd) measured by microiontophoretic technique.[4]

Note legali

ReagentPlus is a registered trademark of Merck KGaA, Darmstadt, Germany

Pittogrammi

Health hazardExclamation mark
GHS08,GHS07

Avvertenze

Warning

Indicazioni di pericolo

H302,H319,H361d

Classi di pericolo

Acute Tox. 4 Oral - Eye Irrit. 2 - Repr. 2

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

208.9 °F - Pensky-Martens closed cup

Punto d’infiammabilità (°C)

98.3 °C - Pensky-Martens closed cup

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Gloves

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Certificati d'analisi (COA)

Lot/Batch Number
WXBF4098V
WXBF4725V
WXBF3023V
WXBF2763V
WXBF1082V

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Effect of Long-Term Sodium Salicylate Administration on Learning, Memory, and Neurogenesis in the Rat Hippocampus
Niu H, et al.
BioMed Research International, 2018, 63-76 (2018)
Local application of sodium salicylate enhances auditory responses in the rat?s dorsal cortex of the inferior colliculus
Patel, Chirag R and Zhang, Huiming
Frontiers in Neurology, 5, 235-235 (2014)
Carmen S Padilla et al.
Frontiers in bioengineering and biotechnology, 8, 977-977 (2020-10-06)
Sugarcane and energy cane (Saccharum spp. hybrids) are ideal for plant-based production of recombinant proteins because their high resource-use efficiency, rapid growth and efficient photosynthesis enable extensive biomass production and protein accumulation at a cost-effective scale. Here, we aimed to
Raul Zavaliev et al.
Cell, 182(5), 1093-1108 (2020-08-19)
In plants, pathogen effector-triggered immunity (ETI) often leads to programmed cell death, which is restricted by NPR1, an activator of systemic acquired resistance. However, the biochemical activities of NPR1 enabling it to promote defense and restrict cell death remain unclear.
Josefa P Alameda et al.
Aging, 11(1), 127-159 (2019-01-12)
CYLD is a deubiquitinating enzyme known for its role as a tumor suppressor whose mutation leads to skin appendages tumors and other cancers. In this manuscript we report that the tumor suppressor CYLD, similarly to other renowned tumor suppressor genes
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Questions

1–2 of 2 Questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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