R7532

RRD-251 hydrochloride

≥98% (HPLC)

• Sinonimo/i: (2,4-Dichlorophenyl)carbamimidothioic acid methyl ester hydrochloride, 2-(2,4-Dichlorobenzyl)-2-thiopseudourea hydrochloride, Rb/Raf-1 disruptor 251 hydrochloride, S-(2,4-Dichlorobenzyl)-isothiouronium hydrochloride
• Formula empirica (notazione di Hill): C₈H₈Cl₂N₂S· HCl
• Numero CAS: 72214-67-6
• Peso molecolare: 271.59
• Numero MDL: MFCD00035047
• Codice UNSPSC: 12352200
• ID PubChem: 329823647
• NACRES: NA.77

Proprietà

• Saggio: ≥98% (HPLC)
• Stato: powder
• Condizioni di stoccaggio: desiccated
• Colore: white to off-white
• Solubilità: DMSO: >10 mg/mL; H₂O: >2 mg/mL
• Temperatura di conservazione: room temp
• Stringa SMILE: Cl.NC(=N)SCc1ccc(Cl)cc1Cl
• InChI: 1S/C8H8Cl2N2S.ClH/c9-6-2-1-5(7(10)3-6)4-13-8(11)12;/h1-3H,4H2,(H3,11,12);1H; COMNQRICZGJVLE-UHFFFAOYSA-N

Descrizione

Azioni biochim/fisiol

RRD-251 hydrochloride is a reversible, potent, and selective disruptor of Rb/Raf-1 interaction.

RRD-251 hydrochloride is a reversible, potent, and selective disruptor of Rb/Raf-1 interaction. The retinoblastoma tumor suppressor protein (Rb) controls the G1-S boundary by repressing the transcriptional activity of the E2F family of transcription factors. Raf-1 kinase binds and phosphorylates Rb early in the G1 phase. RRD-251 significantly inhibits angiogenesis and tumor growth in vivo in an Rb-dependent manner. RRD-251 does not inhibit the binding of B-Raf to Rb and Raf-1 to Mek1/2. Also, RRD-251 does not affect the kinase activities associated with cyclin D, cyclin E, or Raf-1.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3