P8293

Protoporphyrin IX

≥95%

• Sinonimo/i: 3,7,12,17-Tetramethyl-8,13-divinyl-2,18-porphinedipropionic acid, Kammerer’s porphyrin, Ooporphyrin
• Formula empirica (notazione di Hill): C₃₄H₃₄N₄O₄
• Numero CAS: 553-12-8
• Peso molecolare: 562.66
• Beilstein: 380795
• Numero CE: 209-033-7
• Numero MDL: MFCD00151109
• Codice UNSPSC: 41106305
• ID PubChem: 24278655
• NACRES: NA.32

Proprietà

• Livello qualitativo: 100
• Saggio: ≥95%
• Stato: powder
• Fluorescenza: λ_ex 402 nm; λ_em 625 nm (bound to HRP); λ_ex 409 nm; λ_em 633 nm
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: Cc1c(CCC(O)=O)c2cc3[nH]c(cc4nc(cc5[nH]c(cc1n2)c(C)c5C=C)c(C)c4C=C)c(C)c3CCC(O)=O
• InChI: 1S/C34H34N4O4/c1-7-21-17(3)25-13-26-19(5)23(9-11-33(39)40)31(37-26)16-32-24(10-12-34(41)42)20(6)28(38-32)15-30-22(8-2)18(4)27(36-30)14-29(21)35-25/h7-8,13-16,35,38H,1-2,9-12H2,3-6H3,(H,39,40)(H,41,42)/b25-13-,26-13-,27-14-,28-15-,29-14-,30-15-,31-16-,32-16-; KSFOVUSSGSKXFI-UJJXFSCMSA-N

Descrizione

Descrizione generale

Protoporphyrin IX belongs to the porphyrin family, which are a class of tetrapyrroles. It is the iron-free form of hemin and amphiphilic in nature. It is the precursor of heme in its biosynthetic pathway.[1][2][3]

Protoporphyrin IX imparts red color to heme and is the major porphyrin in blood. It is synthesized from protoporphyrinogen IX in the presence of protoporphyrinogen IX oxidase.[4]

Applicazioni

Activates soluble guanylyl cyclase.

Protoporphyrin IX has been used:

• as a standard in protoporphyrin assays[5]
• in fluorescence spectra analysis[6]
• to treat cells in cell culture to study heme-mediated ferroportin 1 transcription[7]

Azioni biochim/fisiol

Protoporphyrin IX penetrates human erythrocytes and aids the release of oxygen from them. It forms complexes with myoglobin and hemoglobin. It is a photosensitizer used in the photodynamic therapy of cancer.[1][2]

Protoporphyrin IX levels are elevated in tumor cells due to metabolism anomalies compared to normal cells.[4]

Informazioni sulla sicurezza

• Pittogrammi: GHS07
• Avvertenze: Warning
• Indicazioni di pericolo: H315,H319,H335
• Consigli di prudenza: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Classi di pericolo: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Organi bersaglio: Respiratory system
• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: dust mask type N95 (US), Eyeshields, Gloves