P5585

Palmitic acid

BioXtra, ≥99%

• Sinonimo/i: 1-Pentadecanecarboxylic acid, C16:0, Cetylic acid, Hexadecanoic acid, NSC 5030, PamOH
• Formula condensata: CH₃(CH₂)₁₄COOH
• Numero CAS: 57-10-3
• Peso molecolare: 256.42
• Beilstein: 607489
• Numero CE: 200-312-9
• Numero MDL: MFCD00002747
• Codice UNSPSC: 12352106
• ID PubChem: 24898674
• NACRES: NA.25

Proprietà

• Origine biologica: plant (vegetable)
• Grado: BioPerformance Certified
• Tensione di vapore: 10 mmHg ( 210 °C)
• Nome Commerciale: BioXtra
• Saggio: ≥99%
• Stato: powder
• tecniche: cell culture | mammalian: suitable
• Impurezze: ≤0.0005% Phosphorus (P); ≤0.1% Insoluble matter
• Residuo alla calcinazione: ≤0.1%
• P. ebollizione: 271.5 °C/100 mmHg (lit.)
• Punto di fusione: 61-62.5 °C (lit.)
• Solubilità: chloroform: 0.5 M, clear, colorless
• Densità: 0.852 g/mL at 25 °C (lit.)
• Anioni in tracce: chloride (Cl^-): ≤0.05%; sulfate (SO₄^2-): ≤0.05%
• Cationi in tracce: Al: ≤0.005%; Ca: ≤0.0005%; Cu: ≤0.0005%; Fe: ≤0.0005%; K: ≤0.005%; Mg: ≤0.0005%; NH₄⁺: ≤0.05%; Na: ≤0.05%; Pb: ≤0.001%; Zn: ≤0.0005%
• Gruppo funzionale: carboxylic acid
• Tipo di lipide: saturated FAs
• Condizioni di spedizione: ambient
• Temperatura di conservazione: room temp
• Stringa SMILE: CCCCCCCCCCCCCCCC(O)=O
• InChI: 1S/C16H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-15H2,1H3,(H,17,18); IPCSVZSSVZVIGE-UHFFFAOYSA-N
• Informazioni sul gene: human ... FABP2(2169) , FABP3(2170) , FABP4(2167) , FABP5(2171)

Descrizione

Applicazioni

Palmitic acid has been used:

• as a medium supplement in chorionic villous tissue culture form placenta[1]
• as a component of hormone pellet for implantation in mice ovary[2]
• for inducing expression of immunity-related GTPase M (IRGM) in human monocytic cell line, THP-1[3]

Azioni biochim/fisiol

Palmitic acid (PA) is a component of membrane phospholipids (PL) and adipose triacylglycerols (TAG).[4] Elevated levels of palmitic acid contributes to the pathophysiology of atherosclerosis, type 2 diabetes mellitus, neurodegenerative diseases, obesity and cancer.[4][5] PA promotes apoptosis in the endothelial cell by modulating the p38 mitogen-activated protein kinase (MAPK) pathway and favors expression of TNF-α and reactive oxygen species accumulation.[6] PA promotes interleukin 8 (IL-8) synthesis in hepatocytes contributing to hepatic inflammation.[7] PA by interacting with toll-like receptor 4 (TLR4) induces inflammatory injury in cardiomyoctes.[8]

Palmitic acid is a straight-chain 16-carbon fatty acid. Diets rich in palmitic acid, along with lauric and myristic acids, are associated with increased serum levels of low-density lipoprotein cholesterol. Palmitic acid is the first fatty acid produced by lipogenesis. It is a negative regulator of acetyl-CoA carboxylase (ACC) and is implicated in fatty acid-induced insulin resistance.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): nwg
• Punto d’infiammabilità (°F): 235.4 °F
• Punto d’infiammabilità (°C): 113 °C
• Dispositivi di protezione individuale: dust mask type N95 (US), Eyeshields, Gloves