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P4380

Sigma-Aldrich

Protamine sulfate

powder

Sinonimo/i:

Salmine, Salmine from salmon

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25 G
CHF 234.00
100 G
CHF 724.00

CHF 234.00

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25 G
CHF 234.00
100 G
CHF 724.00

About This Item

Numero CAS:
53597-25-4
Numero MDL:
MFCD00132091
Codice UNSPSC:
12352202
NACRES:
NA.77

CHF 234.00

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Nome del prodotto

Protamine sulfate salt from salmon, Grade II

Origine biologica

fish (salmon)

Livello qualitativo

200

Tipo

Grade II

Stato

powder

Colore

white to off-white

Solubilità

6 M HCl: 25 mg/mL, clear, colorless to light yellow

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Descrizione generale

Protamine sulfate (PS), a polycationic, positively charged protein[1] is mostly made up of poly(l-arginine).[2] It is obtained from salmon sperm protein.[1]

Applicazioni

May be used for the removal of DNA from protein samples or for the purification of DNA binding proteins. It may be used as an alternative to polybrene in retroviral-mediated gene transfer.

Protamine in the form of solid lipid nanoparticles (SLN) promoted transfection with plasmid DNA more efficiently and with less cytotoxicity than comparable SLNs composed of Esterquat-1.
Protamine in the form of solid lipid nanoparticles (SLN) promoted transfection with plasmid DNA more efficiently and with less cytotoxicity than comparable SLNs composed of Esterquat-1.
Protamine sulfate salt from salmon has been used in the generation of protamine silica nanocomposites.[3]

Azioni biochim/fisiol

Protamine sulfate is a small cationic protein that binds and precipitates DNA. Neutralizes the anticoagulant activity of heparin. Inhibits lipoprotein lipase.
Protamine sulfate is highly preferred in cardiovascular surgical procedures to reverse the anticoagulant properties of heparin.[4] It is used for biomedical and biotechnological applications due to its biodegradablity.[2]

Qualità

May contain insolubles as well as histones.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

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Certificati d'analisi (COA)

Lot/Batch Number
0000368045
0000368044
0000335593
0000335591
0000335593

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Sigma-Aldrich

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Drug-induced pulmonary disease
Murray and Nadel's Textbook of Respiratory Medicine, 1275-1294 (2016)
TLR4 activation by lysozyme induces pain without inflammation.
Yadav, et al.
Frontiers in Immunology, 14, 1065226-1065226 (2023)
Jacob F Warner et al.
Methods in molecular biology (Clifton, N.J.), 1128, 211-221 (2014-02-26)
The Hedgehog pathway has been shown to be an important developmental signaling pathway in many organisms (Ingham and McMahon. Genes Dev 15:3059-3087, 2001). Recently that work has been extended to developing echinoderm embryos (Walton et al. Dev Biol 331(1):26-37, 2009).
Protamine-templated biomimetic hybrid capsules: efficient and stable carrier for enzyme encapsulation
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