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P102

Sigma-Aldrich

R(+)-3-(3-Hydroxyphenyl)-N-propylpiperidine hydrochloride

solid

Sinonimo/i:

R(+)-3-PPP hydrochloride

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About This Item

Formula empirica (notazione di Hill):
C14H21NO · HCl
Numero CAS:
89874-80-6
Peso molecolare:
255.78
Numero MDL:
MFCD00055194
Codice UNSPSC:
12352200
ID PubChem:
24277924
NACRES:
NA.77

Forma fisica

solid

Colore

white

Solubilità

H2O: 150 mg/mL
ethanol: slightly soluble

Stringa SMILE

Cl.CCCN1CCC[C@@H](C1)c2cccc(O)c2

InChI

1S/C14H21NO.ClH/c1-2-8-15-9-4-6-13(11-15)12-5-3-7-14(16)10-12;/h3,5,7,10,13,16H,2,4,6,8-9,11H2,1H3;1H/t13-;/m0./s1
NRHUDETYKUBQJT-ZOWNYOTGSA-N

Informazioni sul gene

human ... DRD2(1813)

Azioni biochim/fisiol

D2 dopamine receptor agonist. Also functions as σ1 receptor antagonist with essentially no affinity for the phencylidine site on the NMDA receptor.

Nota sulla preparazione

Solutions should be freshly prepared.

Note legali

Sold with the permission of Astra Pharmaceutical Co.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

Certificati d'analisi (COA)

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M C Coldwell et al.
British journal of pharmacology, 127(5), 1135-1144 (1999-08-24)
This study characterized pharmacologically the functional responses to agonists at human dopamine D2(long) (hD2), D3 (hD3) and D4.4 (hD4) receptors separately expressed in cloned cells using the cytosensor microphysiometer. Dopaminergic receptor agonists caused increases in extracellular acidification rate in adherent
R Bergeron et al.
Psychopharmacology, 129(3), 215-224 (1997-02-01)
Several high affinity sigma (sigma) ligands, such as DTG, JO-1784, (+)-pentazocine, BD-737 and L-687,384, administered at low doses act as agonists by potentiating N-methyl-D-aspartate (NMDA)-induced activation of pyramidal neurons in the CA3 region of the rat dorsal hippocampus. This potentiation
S Tokuyama et al.
Neuroscience letters, 233(2-3), 141-144 (1997-11-14)
We studied effects of various sigma ligands on GTPase activity in mouse prefrontal membranes. Some representative sigma agonists, such as (+)-pentazocine, SA4503 and (+)-3-PPP, stimulated the GTPase activity in a concentration-dependent manner in ranges of 10 nM to 10 microM.
Jing Yuan et al.
Nature chemical biology, 5(10), 765-771 (2009-09-08)
Studies of gene function and molecular mechanisms in Plasmodium falciparum are hampered by difficulties in characterizing and measuring phenotypic differences between individual parasites. We screened seven parasite lines for differences in responses to 1,279 bioactive chemicals. Hundreds of compounds were
Phedias Diamandis et al.
Nature chemical biology, 3(5), 268-273 (2007-04-10)
The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways that governs the

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