SML0190

ML133 hydrochloride

≥95% (HPLC)

• Sinonimo/i: 1-(4-methoxyphenyl)-N-(naphthalen-1-ylmethyl)methanamine hydrochloride, CID 781301 hydrochloride, N-(4-methoxybenzyl)-1-(naphthalen-1-yl)methanamine hydrochloride, SID 85281105 hydrochloride, VU0404943-1 hydrchloride
• Formula empirica (notazione di Hill): C₁₉H₁₉NO · HCl
• Numero CAS: 1222781-70-5
• Peso molecolare: 313.82
• NACRES: NA.77
• PubChem Substance ID: 329825217
• UNSPSC Code: 12352200
• MDL number: MFCD20921521
• Assay: ≥95% (HPLC)
• Form: powder
• Storage condition: desiccated

Proprietà

• Quality Segment: 100
• assay: ≥95% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to tan
• solubility: DMSO: ≥10 mg/mL
• storage temp.: 2-8°C
• SMILES string: Cl.COc1ccc(CNCc2cccc3ccccc23)cc1
• InChI: 1S/C19H19NO.ClH/c1-21-18-11-9-15(10-12-18)13-20-14-17-7-4-6-16-5-2-3-8-19(16)17;/h2-12,20H,13-14H2,1H3;1H
• InChI key: NGQIBUUFXDPHKT-UHFFFAOYSA-N

Descrizione

Application

ML133 hydrochloride may be used to study cell signaling that involves the function of potassium channels.

ML133 hydrochloride has been used as a Kir2.1 blocker to study the regulation of membrane excitability by inward-rectifier potassium channels (Kir2 family) in the dentate gyrus (DG) granule cells. It has also been used to study the effect of Kir2 on cortical neural activity.

Biochem/physiol Actions

Inhibitor of Kir2 family channels

ML133 hydrochloride is a selective inhibitor of the Kir2 family of inward rectifier (IRK, KCNJ) potassium channels. ML133 inhibits Kir2.1 with IC50 of 1.8 μM at pH 7.4 and 290 nM at pH8.5. It exhibits little selectivity against other members of Kir2.x family channels, but has no effect on Kir1.1 (IC50 > 300 μM), and displays weak activity for Kir4.1 (76 μM) and Kir7.1 (33 μM), making ML133 the most selective small molecule inhibitor of the Kir family reported to date. It also showed modest selectivity versus hERG and a larger panel of GPCRs, ion channels and transporters.

Features and Benefits

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informazioni sulla sicurezza

• Pittogrammi: GHS05,GHS07,GHS09
• Parola di avvertenza: Danger
• Codici di pericolo: H302,H315,H318,H335,H400
• Avvertenze di sicurezza: P273 - P280 - P301 + P312 + P330 - P302 + P352 - P305 + P351 + P338 + P310
• Hazard Classifications: Acute Tox. 4 Oral - Aquatic Acute 1 - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
• Organi bersaglio: Respiratory system
• Classe di stoccaggio: 11 - Combustible Solids
• Che succede?: WGK 3
• Punto di infiammabilità (°F): Not applicable
• Punto di infiammabilità (°C): Not applicable