The molecular weight of this product is not measured as it is not included in the specifications. Therefore, there is no current testing to determine the average length of the current lots in circulation. However, historical data from over a decade ago indicates that past lots were approximately 100-110 kDa (400-1250 bp).
P0913
Polyinosinic–polycytidylic acid sodium salt
γ-irradiated, 10% Poly (I:C) with buffer salts, TLR ligand tested
Sinonimo/i:
Poly (I:C), Poly(I) • Poly(C)
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Cambia visualizzazione
| A voi/SKU | Disponibilità | Prezzo |
|---|---|---|
10 mg | Per conoscere la disponibilità, visualizza il carrello | CHF 262.00 |
50 mg | Per conoscere la disponibilità, visualizza il carrello | CHF 921.00 |
Informazioni su questo articolo
Assay:
(Free nucleotides NMT 1% (TLC))
Biological source:
synthetic (organic)
Form:
lyophilized powder
Solubility:
H2O: 10 mg/mL
Storage temp.:
−20°C
Servizio Tecnico
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Permettici di aiutartibiological source
synthetic (organic)
Quality Segment
sterility
γ-irradiated
assay
(Free nucleotides NMT 1% (TLC))
form
lyophilized powder
storage condition
desiccated
solubility
H2O: 10 mg/mL
storage temp.
−20°C
SMILES string
[Na].[P](=O)(OC[C@H]3O[C@H]([C@@H]([C@@H]3O)O)[n]4c5ncnc(c5nc4)O)(O)O.[P](=O)(OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)N2C=CC(=NC2=O)N)(O)O
InChI
1S/C10H13N4O8P.C9H14N3O8P.Na/c15-6-4(1-21-23(18,19)20)22-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17;10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18;/h2-4,6-7,10,15-16H,1H2,(H,11,12,17)(H2,18,19,20);1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18);/t
InChI key
GETQKWBYQAUFQM-VRQAYDGLSA-N
Application
TLR3 recognizes double-stranded RNA and is a major effector of the immune response against viral pathogens. Polyinosinic–polycytidylic acid (Poly(I) • Poly(C)) is a double-stranded homopolymer used as a model RNA to study cell signaling at the level of TLR3. Poly(IC) is a TRIF-dependent toll-like receptor-3 (TLR3) ligand.
Biochem/physiol Actions
Transfection of Poly (I:C) into NIT-1 cells has been used as a model of intracellular dsRNA-induced β cell apoptosis. Eighteen hours post transfection, 45% of the cells were apoptotic with an increase in NF-kB, p50/p65 nuclear translocation, and cleavage of caspases 3 and 8, as well as transcriptional induction of caspase 12, Fas, IL-15, and the TNF receptor-associated ligand (TRAIL). It has been suggested that Poly(I:C) is one of the most appropriate generators of stable mature dendritic cells (DC). These mature DC might generate in vivo effective immune responses after injection due to their ability to secrete bioactive IL-12 after CD40 ligation. Poly (I:C) was used as a potent adjuvant to enhance the specific anti-tumor immune responses against a peptide-based vaccine.
Preparation Note
The product requires ionic strength to maintain the double-strand structure. To prevent denaturation, reconstitute in solutions with physiological salt concentrations (e.g., saline solution). Reconstitution may require heating (50 °C) and cooling to achieve re-annealing.
Other Notes
Double-stranded homopolymer.
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Questo articolo | |||
|---|---|---|---|
| biological source synthetic (organic) | biological source - | biological source - | biological source synthetic (organic) |
| Quality Level 300 | Quality Level 300 | Quality Level 300 | Quality Level 200 |
| assay ≥99% (less than 1% free nucleotides, TLC) | assay ≥99% (less than 1% free nucleotides, TLC) | assay ≥99% (less than 1% free nucleotides, TLC) | assay ≥98% (TLC) |
| form lyophilized powder | form lyophilized powder | form lyophilized powder | form lyophilized powder |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
| solubility H2O: 10 mg/mL | solubility H2O: 10 mg/mL | solubility - | solubility water: 4.80-5.20 mg/mL, clear to hazy, colorless to faintly yellow |
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Classe di stoccaggio
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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