O3764

Oxcarbazepine

≥98% (HPLC), solid

• Sinonimo/i: 10,11-Dihydro-10-oxo-5h-dibenz[b,f]azepine-5-carboxamide, Oxacarbazepine
• Formula empirica (notazione di Hill): C₁₅H₁₂N₂O₂
• Numero CAS: 28721-07-5
• Peso molecolare: 252.27
• NACRES: NA.77
• PubChem Substance ID: 24724563
• UNSPSC Code: 12352200
• EC Number: 249-188-8
• MDL number: MFCD00865307
• Assay: ≥98% (HPLC)
• Form: solid

Proprietà

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: solid
• color: white
• solubility: DMSO: ~9 mg/mL
• originator: Novartis
• SMILES string: O=C1CC2=C(C=CC=C2)N(C(N)=O)C3=CC=CC=C31
• InChI: 1S/C15H12N2O2/c16-15(19)17-12-7-3-1-5-10(12)9-14(18)11-6-2-4-8-13(11)17/h1-8H,9H2,(H2,16,19)
• InChI key: CTRLABGOLIVAIY-UHFFFAOYSA-N
• Gene Information: human ... SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335) ; rat ... Scnn1g(24768)

Descrizione

General description

Oxcarbazepine (OXC) is the keto-analog of carbamazepine. Unlike carbamazepine, oxcarbazepine has no side effects. It is an antiepileptic drug, with an antineuralgic property. It has a pharmacokinetic advantage over carbamazepine. It is prescribed for neuropathic pain and serves as an effective pain reliever in trigeminal neuralgia.[1] The catabolism of OXC to its monohydroxy derivative has significant pharmacologic property. It modulates potassium channels and voltage-dependent sodium channels.[1] OXC modulates V2 receptor-G protein complex in collecting tubules and is used for treating diabetes insipidus.

Application

Oxcarbazepine has been used in reversed-phase high-performance liquid chromatography of human epileptic brain endothelial cells.

Biochem/physiol Actions

Anticonvulsant, antineuralgic. Inhibits veratrine-induced transmitter release.

Features and Benefits

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informazioni sulla sicurezza

• pictograms: GHS07
• signalword: Warning
• hcodes: H302
• pcodes: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Classe di stoccaggio: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)