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Merck
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N3135

Supelco

Nalorphine hydrochloride

Sinonimo/i:

N-Allylnormorphine HCl, Nalline HCl

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About This Item

Formula empirica (notazione di Hill):
C19H21NO3 · HCl
Numero CAS:
57-29-4
Peso molecolare:
347.84
Numero CE:
200-321-8
Numero MDL:
MFCD00055164
Codice UNSPSC:
41116107

Controllo stupefacenti

USDEA Schedule III; regulated under CDSA - not available from Sigma-Aldrich Canada

Solubilità

H2O: slightly soluble
dilute aqueous acid: soluble
ethanol: soluble

Stringa SMILE

Cl[H].O[C@H]1C=CC2[C@H]3Cc4ccc(O)c5O[C@@H]1[C@]2(CCN3CC=C)c45

InChI

1S/C19H21NO3.ClH/c1-2-8-20-9-7-19-12-4-6-15(22)18(19)23-17-14(21)5-3-11(16(17)19)10-13(12)20;/h2-6,12-13,15,18,21-22H,1,7-10H2;1H/t12?,13-,15+,18+,19+;/m1./s1
NAHATSPWSULUAA-HWXFZQNOSA-N

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Azioni biochim/fisiol

Antagonist at μ receptors, partial agonist at κ receptors, and agonist at sigma receptors, but does not have high affinity for the sigma receptor

Pittogrammi

Exclamation mark
GHS07

Avvertenze

Warning

Indicazioni di pericolo

H302

Classi di pericolo

Acute Tox. 4 Oral

Codice della classe di stoccaggio

13 - Non Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Gloves

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Certificati d'analisi (COA)

Lot/Batch Number
099H3358
124F0744
103H3384
088F0121
034H3369

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M R Bouw et al.
Pharmaceutical research, 15(11), 1673-1679 (1998-12-02)
To investigate the performance of two alternative retrodialysis recovery methods and to describe the influence of different recoveries on the reliability in estimating unbound extracellular concentrations of morphine. Unbound concentrations of morphine in striatum and in blood were determined by
D M Sherman et al.
Patologicheskaia fiziologiia i eksperimental'naia terapiia, (2)(2), 11-14 (2004-06-24)
Acute experiments on 75 adult rabbits were made to study action of intravenous injections of naloxone (0.1 mg/kg), nalorphine (0.5 and 2.0 mg/kg) and dalargin (0.1 mg/kg) in early and late periods of irreversible shock caused by combination of non-shockogenic
R Xie et al.
Pharmaceutical research, 15(4), 570-575 (1998-05-20)
The purpose of the study was to investigate the distribution of codeine across the blood-brain barrier (BBB) in rats by microdialysis (MD). Rats were administered intravenous infusion of codeine in doses of (1) 10 mg/kg, (2) 20 mg/kg for 10
C Y Cheng et al.
Bioorganic & medicinal chemistry, 4(1), 73-80 (1996-01-01)
N-Cubylmethylnormorphine (1) and N-cubylmethylnoroxymorphone (2) have been synthesized and found to be more potent ligands at the mu and kappa opioid receptors than morphine and oxymorphone respectively. In the guinea-pig ileum preparation, compounds 1 and 2 were characterized as opioid
C D King et al.
Drug metabolism and disposition: the biological fate of chemicals, 25(2), 251-255 (1997-02-01)
Opioids are important drugs used as analgesics, antitussives, antidiarrheals, and in the therapy of myocardial infarctions, and as antagonists of opioid intoxication. The glucuronidation of these compounds, catalyzed by UDP-glucuronosyltransferases (UGTs), is well known to be a primary step in
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