Documenti fondamentali

Visualizza tutta la documentazione

Vai a

M6690

MDL 28170

Name: MDL 28170
Brand: SIGMA

≥90% (TLC), calpain I and II inhibitor

Sinonimo/i:

Calpain Inhibitor III

Autenticati per visualizzare i prezzi organizzativi e contrattuali.

Scegli un formato

Cambia visualizzazione

A voi/SKU	Disponibilità	Prezzo

Informazioni su questo articolo

Formula empirica (notazione di Hill):

C₂₂H₂₆N₂O₄

Numero CAS:

88191-84-8

Peso molecolare:

382.45

UNSPSC Code:

12352200

PubChem Substance ID:

24278565

NACRES:

NA.77

MDL number:

MFCD00798796

Assay:

≥90% (TLC)

Prezzi e disponibilità al momento non sono disponibili

Servizio Tecnico

Hai bisogno di aiuto? Il nostro team di scienziati qualificati è a tua disposizione.

Permettici di aiutarti

Proprietà

Nome del prodotto

MDL 28170, ≥90% (TLC)

Quality Segment

200

assay

≥90% (TLC)

composition

Peptide Content, >90%

solubility

DMSO: 26 mg/mL, H₂O: insoluble, methanol: soluble

shipped in

wet ice

storage temp.

2-8°C

SMILES string

[H]C(=O)C(Cc1ccccc1)NC(=O)[C@@H](NC(=O)OCc2ccccc2)C(C)C

InChI

1S/C22H26N2O4/c1-16(2)20(24-22(27)28-15-18-11-7-4-8-12-18)21(26)23-19(14-25)13-17-9-5-3-6-10-17/h3-12,14,16,19-20H,13,15H2,1-2H3,(H,23,26)(H,24,27)/t19?,20-/m0/s1

InChI key

NGBKFLTYGSREKK-ANYOKISRSA-N

Gene Information

human ... CAPN1(823), CAPN2(824)

Descrizione

Application

MDL 28170 has been used as a calpain inhibitor:

to study its effects on neuroinflammation and necroptosis in rat model of cardiac arrest[1]
to analyze its effects on the degradation of neuronal nitric oxide synthase (nNOS) in beef semimembranosus muscle[2]
to study its protective effects against traumatic brain injury and survival of bone marrow-derived mesenchymal stem cells (BMSCs) in rat brain[3]

Biochem/physiol Actions

MDL 28170 exhibits neuroprotective effects against spinal cord injury, focal cerebral ischemia, and neonatal hypoxia-ischemia in rats.[4] It also shows anti-inflammatory and anti-neurodegenerative properties.[3] MDL 28170 crosses the blood-brain barrier and penetrates readily through the cell membranes.[1]

MDL 28170 is a potent cell permeable calpain I and II inhibitor; reduces capsaicin-mediated cell death in cultured dorsal root ganglion neurons. Reduced occurrence of apoptosis in H₂O₂ and A23187 treated PC12 cells. γ-secretase-inhibitor.

Potent cell permeable calpain I and II inhibitor; reduces capsaicin-mediated cell death in cultured dorsal root ganglion neurons.

Confronta articoli simili

Visualizza il confronto per intero

Mostra le differenze

1 of 1

Questo articolo	208722	208743	444264
Sigma-Aldrich M6690 MDL 28170	Sigma-Aldrich 208722 Calpain Inhibitor III	Sigma-Aldrich 208743 Calpain Inhibitor XI	Sigma-Aldrich 444264 MMP Inhibitor III
assay ≥90% (TLC)	assay ≥95% (HPLC)	assay ≥95% (HPLC)	assay ≥90% (TLC)
Quality Level 200	Quality Level 100	Quality Level 100	Quality Level 100
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. −20°C
solubility DMSO: 26 mg/mL, methanol: soluble, H₂O: insoluble	solubility DMSO: 20 mg/mL (Use only anhydrous DMSO.)	solubility DMSO: 5 mg/mL	solubility DMSO: 5 mg/mL
Gene Information human ... CAPN1(823), CAPN2(824)	Gene Information -	Gene Information -	Gene Information -
composition Peptide Content, >90%	composition -	composition -	composition -

Classe di stoccaggio

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Scegli una delle versioni più recenti:

Certificati d'analisi (COA)

Lot/Batch Number

It looks like we've run into a problem, but you can still download Certificates of Analysis from our Documenti section.

Se ti serve aiuto, non esitare a contattarci Servizio Clienti

Possiedi già questo prodotto?

I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.