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M6418

Sigma-Aldrich

Manumycin A from Streptomyces parvulus

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About This Item

Formula empirica (notazione di Hill):
C31H38N2O7
Numero CAS:
52665-74-4
Peso molecolare:
550.64
Numero MDL:
MFCD00920782
Codice UNSPSC:
12352200
ID PubChem:
24897011
NACRES:
NA.32

Saggio

≥97% (HPLC)

Livello qualitativo

200

Forma fisica

powder

Solubilità

methanol: 9.80-10.20 mg/mL, clear, yellow to very deep yellow

Temperatura di conservazione

2-8°C

Stringa SMILE

CCCC[C@@H](C)\C=C(C)\C=C(/C)C(=O)NC1=C[C@@](O)(\C=C\C=C\C=C\C(=O)NC2=C(O)CCC2=O)[C@@H]3O[C@H]3C1=O

InChI

1S/C31H38N2O7/c1-5-6-11-19(2)16-20(3)17-21(4)30(38)32-22-18-31(39,29-28(40-29)27(22)37)15-10-8-7-9-12-25(36)33-26-23(34)13-14-24(26)35/h7-10,12,15-19,28-29,34,39H,5-6,11,13-14H2,1-4H3,(H,32,38)(H,33,36)/b8-7+,12-9+,15-10+,20-16+,21-17+/t19-,28?,29-,31+/m1/s1
TWWQHCKLTXDWBD-YCWSEAROSA-N

Applicazioni

Manumycin A from Streptomyces parvulus has been used to inhibit IκB kinase (IKK)b−nuclear κ-B essential modulator (NEMO) interaction in the homogeneous time-resolved fluorescence (HTRF)-based binding assay.

Azioni biochim/fisiol

Manumycin A is a natural monomeric epoxyquinoid. It has an ability to inhibit tumor necrosis factor (TNF) induced IκB kinase (IKK) activity in various cell types. In addition, manumycin A exhibits anti-tumor property by inhibiting farnesylation of oncogenic Ras.
Potent inhibitor of Ras farnesyltransferase.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Daniel Z Bar et al.
Nucleus (Austin, Tex.), 1(6), 499-505 (2011-02-18)
Fibroblasts derived from Hutchinson-Gilford progeria syndrome (HGPS) patients and dermal cells derived from healthy old humans in culture display age-dependent progressive changes in nuclear architecture due to accumulation of farnesylated lamin A. Treating human HGPS cells or mice expressing farnesylated
Vivek Sharma et al.
Inflammation, 35(2), 516-519 (2011-05-11)
We have recently reported that Ras acts as an intermediate coactivator in IL-1β-mediated hypoxia-inducible factor-1α (HIF-1α) activation in glioblastoma multiforme (GBM). Since HIF-1α plays a crucial role in linking inflammatory and oncogenic pathways, we investigated whether this IL1β-Ras-HIF-1α signaling axis
A homogeneous time-resolved fluorescence-based high-throughput screening system for discovery of inhibitors of IKK$\beta$--NEMO interaction
Gotoh Y, et al.
Analytical Biochemistry, 405(1), 19-27 (2010)
Pengfei Xie et al.
Applied microbiology and biotechnology, 96(2), 451-460 (2012-05-05)
Asukamycin, a member of the manumycin family of antibiotics, exhibits strong antibacterial, antifungal, and antineoplastic activities. However, its production in the wild-type strain of Streptomyces nodosus subsp. asukaensis ATCC 29757 is relatively low. Recently, the biosynthetic gene cluster for asukamycin
Fuchao Li et al.
Journal of bacteriology, 193(13), 3417-3418 (2011-05-10)
Streptomyces griseoaurantiacus M045, isolated from marine sediment, produces manumycin and chinikomycin antibiotics. Here we present a high-quality draft genome sequence of S. griseoaurantiacus M045, the first marine Streptomyces species to be sequenced and annotated. The genome encodes several gene clusters
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