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M5435

Sigma-Aldrich

6-Methyl-2-(phenylethynyl)pyridine hydrochloride

≥98% (HPLC)

Sinonimo/i:

MPEP hydrochloride

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About This Item

Formula empirica (notazione di Hill):
C14H11N · HCl
Numero CAS:
219911-35-0
Peso molecolare:
229.70
Numero MDL:
MFCD02262119
Codice UNSPSC:
12352200
ID PubChem:
24278557
NACRES:
NA.77

Saggio

≥98% (HPLC)

Forma fisica

powder

Colore

off-white to light tan

Solubilità

DMSO: 10 mg/mL, clear

Temperatura di conservazione

room temp

Stringa SMILE

Cl.Cc1cccc(n1)C#Cc2ccccc2

InChI

1S/C14H11N.ClH/c1-12-6-5-9-14(15-12)11-10-13-7-3-2-4-8-13;/h2-9H,1H3;1H
PKDHDJBNEKXCBI-UHFFFAOYSA-N

Informazioni sul gene

human ... GRIN2B(2904) , GRM5(2915)
rat ... Grm5(24418)

Descrizione generale

GRIN2B (glutamate ionotropic receptor NMDA type subunit 2B) codes for N-methyl d-aspartate receptor subtype 2B (GluN2B). It belongs to the N-methyl-D-aspartate receptor (NMDAR) gene family. It is located on chromosome 12p13.1.

Applicazioni

6-Methyl-2-(phenylethynyl)pyridine hydrochloride has been used to investigate whether 3, 4 (±) methylenedioxymethamphetamine (MDMA) could influence self-renewal via the mGlu5 receptor in mouse embryonic stem cells (mESCs).

Azioni biochim/fisiol

GRIN2B (glutamate ionotropic receptor NMDA type subunit 2B) plays an important role in the growth of neurons and is highly essential for learning and memory. GRIN2B mutation is associated with neuropsychiatric and developmental disorders like schizophrenia, Parkinson′s disease and bipolar disorder. MPEP (2-methyl-6-(phenylethynyl)pyridine hydrochloride) is used to treat Alzheimer′s disease (AD).
Highly selective, non-competitive mGluR5 metabotropic glutamate receptor antagonist.

Caratteristiche e vantaggi

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Glutamate Receptors (G Protein Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Pifithrin-α ≥95% (HPLC), powder

Sigma-Aldrich

P4359

Pifithrin-α

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Patients with chronic pain easily accompany the negative mood symptoms such as depression and anxiety, and these disturbances in turn affect the aversive perception of pain. However, the underlying mechanisms are largely unknown. We hypothesized that the alteration of metabotropic
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Maternal immune challenge has proved to induce moderate to severe behavioral disabilities in the offspring. Cognitive/behavioral deficits are supported by changes in synaptic plasticity in different brain areas. We have reported previously that prenatal exposure to bacterial LPS could induce
Human GRIN2B variants in neurodevelopmental disorders
Hu C, et al.
Journal of Pharmacological Sciences, 132(2), 115-121 (2016)
F Gasparini et al.
Neuropharmacology, 38(10), 1493-1503 (1999-10-26)
In the present paper we describe 2-methyl-6-(phenylethynyl)-pyridine (MPEP) as a potent, selective and systemically active antagonist for the metabotropic glutamate receptor subtype 5 (mGlu5). At the human mGlu5a receptor expressed in recombinant cells, MPEP completely inhibited quisqualate-stimulated phosphoinositide (PI) hydrolysis
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