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CdO/CdA

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M2922

3-Methyl-6-[3-(trifluoromethyl)phenyl]-1,2,4-triazolo[4,3-b]pyridazine

Name: 3-Methyl-6-[3-(trifluoromethyl)phenyl]-1,2,4-triazolo[4,3-b]pyridazine
Brand: SIGMA

Sinonimo/i:

CL 218,872

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About This Item

Formula empirica (notazione di Hill):

C₁₃H₉F₃N₄

Numero CAS:

66548-69-4

Peso molecolare:

278.23

Numero MDL:

MFCD00674912

Codice UNSPSC:

12352200

ID PubChem:

24278545

Temperatura di conservazione

2-8°C

Stringa SMILE

Cc1nnc2ccc(nn12)-c3cccc(c3)C(F)(F)F

Informazioni sul gene

human ... BZRAP1(9256) , GABRA1(2554) , GABRA2(2555) , GABRA3(2556) , GABRA5(2558) , GABRA6(2559) , GABRG2(2566)

Azioni biochim/fisiol

Selective agonist at the BZ_I benzodiazepine receptor.

Pittogrammi

GHS07

Avvertenze

Warning

Indicazioni di pericolo

H315,H319,H335

Consigli di prudenza

P261 - P305 + P351 + P338

Classi di pericolo

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Gloves

Certificati d'analisi (COA)

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Bicyclic [b]-heteroannulated pyridazine derivatives--II. Structure-activity relationships in the 6-aryltriazolo-[4,3-b]pyridazine ligands of the benzodiazepine receptor.

J Karolak-Wojciechowska et al.

Bioorganic & medicinal chemistry, 2(8), 773-779 (1994-08-01)

Electronic parameters (molecular electrostatic potential MEP, charge distribution on the nitrogen atoms, dipole moment mu and ionization potential IP) were calculated by semiempirical quantum chemistry methods for 2 sets (X = H and m-CF3, the syn- and anti-rotamers of the

CL 218,872 a triazolopyridazine with a selective affinity for the benzodiazepine BZ1 receptor subtype, retards the development and expression of amygdaloid-kindled seizures: effects of flumazenil.

R K McNamara et al.

Epilepsy research, 16(1), 19-26 (1993-09-01)

To clarify the role of benzodiazepine receptors in kindling, the present experiment assessed the effects of CL 218,872 (1, 5, 10, and 20 mg/kg), a triazolopyridazine with a selective affinity for the putative benzodiazepine BZ1 receptor subtype, on the development

Differences in expression of GABAA receptor subunits, but not benzodiazepine binding, in the chick brainstem auditory system.

R L Hyson et al.

Journal of molecular neuroscience : MN, 8(3), 193-205 (1997-06-01)

Neurons in nucleus magnocellularis (NM) and nucleus laminaris (NL) of the chick brainstem auditory system show an unusual physiological response to GABA. Examination of these nuclei using in situ hybridization for GABAA receptor subunits showed a differential expression of the

Coincidental appearance of the alpha 1 subunit of the GABA-A receptor and the type I benzodiazepine receptor near birth in macaque monkey visual cortex.

A Hendrickson et al.

International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 12(4), 299-314 (1994-06-01)

The expression of subtypes of the GABA-A/benzodiazepine receptor complex has been studied during pre- and postnatal development of Macaca monkey visual cortex using complementary radioligand and immunocytochemical labeling. Type I benzodiazepine receptors were labeled directly by [3H]zolpidem. Type II receptors

Ontogeny of two different benzodiazepine binding sites in the chick optic lobe.

M C Gravielle et al.

Neuroreport, 6(15), 2013-2016 (1995-10-23)

The developmental time-course of type I and type II benzodiazepine receptors in the chick optic lobe was determined using a triazolopyridazine, CL 218872. At embryonic day 13 most of the binding sites corresponded to type II (98.23%), while type I

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