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M0757

Sigma-Aldrich

Isopropyl myristate

≥90% (GC)

Sinonimo/i:

Isopropyl tetradecanoate, Myristic acid isopropyl ester

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About This Item

Formula condensata:
CH3(CH2)12COOCH(CH3)2
Numero CAS:
110-27-0
Peso molecolare:
270.45
Beilstein:
1781127
Numero CE:
203-751-4
Numero MDL:
MFCD00008982
Codice UNSPSC:
12352211
ID PubChem:
57654344
NACRES:
NA.25

Origine biologica

synthetic (organic)

Saggio

≥90% (GC)

Forma fisica

liquid

Indice di rifrazione

n20/D 1.434 (lit.)

P. eboll.

193 °C/20 mmHg (lit.)

Punto di fusione

~3 °C (lit.)

Densità

0.85 g/mL at 25 °C (lit.)

Gruppo funzionale

ester

Tipo di lipide

saturated FAs

Condizioni di spedizione

ambient

Temperatura di conservazione

2-8°C

Stringa SMILE

CCCCCCCCCCCCCC(=O)OC(C)C

InChI

1S/C17H34O2/c1-4-5-6-7-8-9-10-11-12-13-14-15-17(18)19-16(2)3/h16H,4-15H2,1-3H3
AXISYYRBXTVTFY-UHFFFAOYSA-N

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Applicazioni


  • Formulation design and development of matrix diffusion controlled transdermal drug delivery of glimepiride.: This study discusses the design of a transdermal drug delivery system for glimepiride, utilizing matrix diffusion mechanisms potentially incorporating Isopropyl Myristate to enhance permeation (Akram et al., 2018).

  • Investigation of microemulsion and microemulsion gel formulations for dermal delivery of clotrimazole.: This article evaluates formulations incorporating Isopropyl Myristate for enhanced dermal delivery of clotrimazole, highlighting its role in improving drug solubility and skin absorption rates (Zhang and Michniak-Kohn, 2018).

Azioni biochim/fisiol

Isopropyl myristate (myristic acid isopropyl ester) is used to change the physicochemical characteristics of microsheres such as poly(lactic-co-glycolic acid) (PLGA) microspheres. Isopropyl myristate is used as a oil phase component in the formulation of microemulsion systems.

Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

awg

Punto d’infiammabilità (°F)

>302.0 °F

Punto d’infiammabilità (°C)

> 150 °C

Dispositivi di protezione individuale

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Eva Abramov et al.
Journal of colloid and interface science, 591, 363-372 (2021-02-24)
Modified microemulsions (MEs), termed by us nanodomains (NDs), seem to be suitable vehicles for dermal drug delivery due to their high surface area and the interface enriched with membrane recognizing agents, penetration enhancers, and other components. However, liquid nanodomains do
Mahendra Singh et al.
Journal of controlled release : official journal of the Controlled Release Society, 328, 895-916 (2020-10-19)
The eye is the specialized part of the body and is comprised of numerous physiological ocular barriers that limit the drug absorption at the action site. Regardless of various efforts, efficient topical ophthalmic drug delivery remains unsolved, and thus, it
Qian Zhang et al.
Pharmaceutical research, 30(1), 32-40 (2012-08-28)
In principle, maximum transepidermal fluxes of solutes should be similar for different vehicles, except when the solute or vehicle modifies the skin. Here we estimated maximum flux, stratum corneum solubility, diffusivity and permeability coefficient for a range of similarly sized
Ji Zhang et al.
International journal of pharmaceutics, 421(1), 34-44 (2011-10-01)
In this study, microemulsion microstructures, key formulation variables, and their relationship to drug transdermal permeation enhancement were investigated. A microemulsion system with high water soluble capacity was developed, using isopropyl myristate, Labrasol, and Cremophor EL as oil, surfactant, and co-surfactant
Fan Yang et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 82(1), 158-163 (2012-06-21)
Transdermal delivery of methotrexate (MTX) was investigated by using the solid-in-oil (S/O) technique. Because MTX was coated with nonionic surfactant molecules, the resulting complex was easy to dissolve in various organic solvents and provided a transparent solution in isopropyl myristate
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