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I6659

Sigma-Aldrich

Imperatorin

≥98% (HPLC), powder

Sinonimo/i:

9-[(3-METHYL-2-BUTEN-1-YL)OXY]-7H-FURO[3,2-G][1]BENZOPYRAN-7-ONE

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About This Item

Formula empirica (notazione di Hill):
C16H14O4
Numero CAS:
482-44-0
Peso molecolare:
270.28
Numero CE:
207-581-1
Numero MDL:
MFCD00016881
Codice UNSPSC:
12352200
ID PubChem:
329815395
NACRES:
NA.77

Livello qualitativo

100

Saggio

≥98% (HPLC)

Stato

powder

Colore

off-white to light brown

Solubilità

DMSO: ≥5 mg/mL

Temperatura di conservazione

2-8°C

Stringa SMILE

C\C(C)=C\COc1c2OC(=O)C=Cc2cc3ccoc13

InChI

1S/C16H14O4/c1-10(2)5-7-19-16-14-12(6-8-18-14)9-11-3-4-13(17)20-15(11)16/h3-6,8-9H,7H2,1-2H3
OLOOJGVNMBJLLR-UHFFFAOYSA-N

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Azioni biochim/fisiol

Imperatorin is a modulator of p38, ERK pathway. Imperatorin increases BMP-2 expression (mRNA) and increases bone density/volume and mineralization in vivo.
Imperatorin is an important bioactive furanocoumarin. It is used to treat neurodegenerative diseases. It possesses anticancer, antibacterial, anti-inflammatory and HIV replication-inhibiting activities. Imperatorin serves as an inhibitor of acetylcholinesterase (AChE) and may help in treating Alzheimer′s disease (AD) and Parkinson′s disease (PD).

Caratteristiche e vantaggi

This compound is featured on the MAPKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Pittogrammi

Exclamation mark
GHS07

Avvertenze

Warning

Indicazioni di pericolo

H302,H315,H317,H319,H335

Classi di pericolo

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

Organi bersaglio

Respiratory system

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

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Certificati d'analisi (COA)

Lot/Batch Number
0000296806
0000248172
0000296806
0000184249
0000184248

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Glycyrrhizic acid United States Pharmacopeia (USP) Reference Standard

USP

1295888

Glycyrrhizic acid

Umbelliferone 99%

Sigma-Aldrich

H24003

Umbelliferone

Glycyrrhizic Acid Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1516

Glycyrrhizic Acid

Yan Zhang et al.
Fitoterapia, 83(1), 60-66 (2011-10-11)
Augmented endothelial nitric oxide (NO) synthase (eNOS) signaling has been reported to be associated with improvements in cardiac remodeling, and NO levels have been shown to be related to cardiac hypertrophy and heart failure. Imperatorin, a dietary furanocoumarin, has been
Zhangqian Wang et al.
Pest management science, 68(7), 1041-1047 (2012-03-06)
An assessment was made of the toxicity of imperatorin and osthole identified in Cnidium monnieri fruit, 11 related compounds and five insecticides to larvae from insecticide-susceptible Culex pipiens pallens (KS-CP strain) and Aedes aegypti and wild C.p. pallens (YS-CP colony)
Xia Lv et al.
Food chemistry, 138(4), 2260-2266 (2013-03-19)
Imperatorin (IMP) is a major constituent of many herbal medicines and possesses anti-osteoporosis activity. The present research work aimed to study the biotransformation processes of IMP and evaluated the anti-osteoporosis activity of the transformed metabolites. Among 18 strains of filamentous
Ke-wang Luo et al.
Chemotherapy, 57(6), 449-459 (2011-12-23)
Imperatorin (IM) is a furanocoumarin isolated from the root of Angelica dahurica, which is reported to have anticonvulsant and anticancer effects. In this study, the antiproliferative effect of IM on 9 human cancer cell lines was examined, and human hepatoma
Hyun-A Oh et al.
The Journal of pharmacology and experimental therapeutics, 339(1), 72-81 (2011-07-07)
Because imperatorin (IPT), the furanocoumarins exhibits anti-inflammatory activity, we reasoned that IPT might modulate the allergic rhinitis (AR). The aim of this study was to analyze the regulation of AR by IPT. Here, we show the effect and mechanism of
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