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I5159
Imiquimod
≥98% (HPLC), solid, caspase 3 activator
Sinonimo/i:
1-(2-Methylpropyl)-1H-imidazole[4,5-c]quinoline-4-amine
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Cambia visualizzazione
200 MG
CHF 266.00
About This Item
Formula empirica (notazione di Hill):
C14H16N4
Numero CAS:
Peso molecolare:
240.30
Numero MDL:
Codice UNSPSC:
12352200
ID PubChem:
NACRES:
NA.77
Prodotti consigliati
Nome del prodotto
Imiquimod, ≥98% (HPLC), solid
Saggio
≥98% (HPLC)
Stato
solid
Solubilità
H2O: <2 mg/mL
DMSO: 4 mg/mL (warming to 60 °C for 15 minutes)
Stringa SMILE
CC(C)Cn1cnc2c(N)nc3ccccc3c12
InChI
1S/C14H16N4/c1-9(2)7-18-8-16-12-13(18)10-5-3-4-6-11(10)17-14(12)15/h3-6,8-9H,7H2,1-2H3,(H2,15,17)
DOUYETYNHWVLEO-UHFFFAOYSA-N
Informazioni sul gene
human ... TLR7(51284)
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Descrizione generale
Imiquimod is a toll-like receptor (TLR)-7/8 agonist.[1]
Applicazioni
Azioni biochim/fisiol
Imiquimod helps to induce the innate cutaneous immunity and the cellular arm of the adaptive immune response.[1]
Imiquimod is a caspase 3 activator, which directly induces procaspase 3 cleavage to active caspase 3. Imiquimod induces apoptosis in vivo in basal cell carcinoma. Its anti-tumor activity is related to the induction of apoptosis. Imiquimod has anti-angiogenic, anti-inflammatory, anti-viral activities. Imiquimod also acts as an immune response modulator inducing the secretion of various cytokines and chemokines.
Imiquimod is a caspase 3 activator, which directly induces procaspase 3 cleavage to active caspase 3. Imiquimod induces apoptosis in vivo and acts as an immunomodulator with anti-viral and anti-inflammatory perties.
Caratteristiche e vantaggi
This compound is featured on the Caspases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Avvertenze
Danger
Indicazioni di pericolo
Consigli di prudenza
Classi di pericolo
Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2
Codice della classe di stoccaggio
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Dispositivi di protezione individuale
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
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Aldara is a cream used for topical treatment of non-melanoma skin cancer, and is thought to act through stimulation of anti-tumour immunity. The active ingredient, imiquimod, has been shown to stimulate toll-like receptor 7. Aldara also induces psoriasis-like lesions when
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