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I0879

Sigma-Aldrich

Inosine 5′-triphosphate trisodium salt

≥95%

Sinonimo/i:

ITP

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About This Item

Formula empirica (notazione di Hill):
C10H12Na3N4O14P3
Numero CAS:
35908-31-7
Peso molecolare:
574.11
Numero MDL:
MFCD00084678
Codice UNSPSC:
41106305
ID PubChem:
24895910
NACRES:
NA.51

Saggio

≥95%

Condizioni di spedizione

dry ice

Temperatura di conservazione

−20°C

Stringa SMILE

[Na].OC1C(O)C(OC1COP(O)(=O)OP(O)(=O)OP(O)(O)=O)n2cnc3C(=O)N=CNc23

InChI

1S/C10H15N4O14P3.Na.H/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17;;/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20);;
RIERCUPIZLBNFQ-UHFFFAOYSA-N

Informazioni sul gene

human ... HRAS(3265)

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Categorie correlate

Applicazioni

Inosine 5′-triphosphate (ITP) is used in studies on the impact of deamination of ATP and GTP by various enzymes and chemical processes. ITP may be used as a substrate to study the specificity and kinetics of nucleoside-5′-triphosphatase and ATPase. ITP is also used to study activation of various ATPases and GTPases.
Inosine 5′-triphosphate trisodium salt has been used to investigate its influence on the chromosome aberration rate, the mitotic rate, sister-chromatid exchange (SCE) frequency, the proportion of first (X1), second (X2) and third (X3) division metaphases of human peripheral lymphocytes.

Azioni biochim/fisiol

Inosine 5′-triphosphate (ITP) has the ability to support the initiation of effector system. It can prevent guanosine 5′-triphosphate (GTP) hydrolysis, that is catalysed by transducin (TD). ITP can proficiently induce secretion in permeabilized cells than GTP. Instead of GTP, ITP can be used for the initiation and the elongation steps of reovirus transcription. ITP can also replace GTP in the activation of G-protein.

Nota sulla preparazione

Prepared from Bacterial ATP

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

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As to the clastogenic-, sister-chromatid exchange inducing-and cytotoxic activity of inosine triphosphate in cultures of human peripheral lymphocytes
Vormittag W and Brannath W
Mutation Research, 476(1), 71-81 (2001)
T Toyo-oka
Circulation research, 49(6), 1350-1355 (1981-12-01)
The contraction of cardiac muscle that has been treated with glycerol requires Ca2+ (pCa 8-5), when MgATP is used as a substrate. In contrast, this preparation contracts, even in the absence of Ca2+ (pCa 8-10), when ATP is replaced by
Initiation of reovirus transcription by inosine 5'-triphosphate and properties of 7-methylinosine-capped, inosine-substituted messenger ribonucleic acids
Morgan M A and Shatkin A J
Biochemistry, 19(26), 5960-5966 (1980)
D Pollard-Knight et al.
The Biochemical journal, 245(3), 625-629 (1987-08-01)
When ATP, the normal phosphate donor for hexokinase D ('glucokinase'), is replaced by ITP, the positive co-operativity with respect to glucose disappears. This may be rationalized in relation to kinetic models for hexokinase D co-operativity, which assume that with the
I M Rusina et al.
Biomeditsinskaia khimiia, 52(4), 364-369 (2006-10-19)
Activity and some properties of a soluble enzyme hydrolyzing nucleoside-5'-triphosphates were studied in the liver and kidney of normal and diabetic rats. The enzyme activity was shown to be reduced by 34% (p < 0.01) in the liver extracts of
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