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Merck
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Documenti fondamentali

HPA038736

Sigma-Aldrich

Anti-ANKRD1 antibody produced in rabbit

enhanced validation

Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

Sinonimo/i:

Anti-ALRP, Anti-C-193, Anti-CARP, Anti-CVARP, Anti-MCARP, Anti-ankyrin repeat domain 1 (cardiac muscle)

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About This Item

Codice UNSPSC:
12352203
Numero Human Protein Atlas:

Origine biologica

rabbit

Coniugato

unconjugated

Forma dell’anticorpo

affinity isolated antibody

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Nome Commerciale

Prestige Antibodies® Powered by Atlas Antibodies

Stato

buffered aqueous glycerol solution

Reattività contro le specie

human

Convalida avanzata

orthogonal RNAseq
Learn more about Antibody Enhanced Validation

tecniche

immunofluorescence: 0.25-2 μg/mL
immunohistochemistry: 1:20-1:50

Sequenza immunogenica

RYKMIRLLIMYGADLNIKNCAGKTPMDLVLHWQNGTKAIFDSLRENSYKTSRIATF

N° accesso UniProt

Condizioni di spedizione

wet ice

Temperatura di conservazione

−20°C

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... ANKRD1(27063)

Descrizione generale

The ankyrin repeat domain 1 (ANKRD1) gene mapped to human 10q23.33, encodes cardiac adriamycin responsive protein (CARP). The encoded nuclear protein is a member of the muscle ankyrin repeat proteins family. Members of this family contain four ankyrin repeats constituting a conserved motif. ANKRD1 is mainly expressed in heart during embryonic and fetal development.

Immunogeno

ankyrin repeat domain 1 (cardiac muscle) recombinant protein epitope signature tag (PrEST)

Applicazioni

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies® protocols and other useful information.

Azioni biochim/fisiol

Ankyrin repeat domain 1 (ANKRD1) might act as a transcriptional negative regulator for Ventricular myosin light chain-2 (MLC-2v) in cardiac myogenesis. The encoded protein plays a vital role in cardiac muscle function in both physiological and pathological conditions. Additionally, it is also implicated in the regulation of gene expression in the heart. Variations in the gene expression leads to hypertrophic cardiomyopathy (HCM) and human dilated cardiomyopathy. ANKRD1 functions as a transcriptional co-activator and enhances tumor suppressive activity of p53 protein.

Caratteristiche e vantaggi

Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:
  • IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
  • Protein array of 364 human recombinant protein fragments.

Linkage

Corresponding Antigen APREST80281

Stato fisico

Solution in phosphate buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide.

Note legali

Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

WGK 1


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Assignment of the murine ankyrin-repeated protein gene (Ankrd2) to mouse chromosome 19C3-->D1 and rat chromosome 1q51-->q53 by fluorescence in situ hybridization.
Fujiwara M
Cytogenetic and genome research, 105 (2004)
Mapping of porcine ANKRD1, ANKRD2, ANKRD23, VGLL2 and VGLL4 using somatic cell and radiation hybrid panels.
Dong XJ
Animal Genetics, 38, 424-425 (2007)
A novel role for cardiac ankyrin repeat protein Ankrd1/CARP as a co-activator of the p53 tumor suppressor protein.
Kojic S
Archives of Biochemistry and Biophysics, 502, 60-67 (2010)
Cardiac ankyrin repeat protein gene (ANKRD1) mutations in hypertrophic cardiomyopathy.
Arimura T
Journal of the American College of Cardiology, 54, 334-342 (2009)
Mutations in the ANKRD1 gene encoding CARP are responsible for human dilated cardiomyopathy.
Duboscq-Bidot L
European Heart Journal, 30, 2128-2136 (2009)

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