H7654
Hydroxyguanidine sulfate salt
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50 MG
CHF 351.00
CHF 351.00
Spedizione prevista il30 maggio 2025
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50 MG
CHF 351.00
About This Item
Formula condensata:
CH5N3O · 1/2H2SO4
Numero CAS:
Peso molecolare:
124.11
Numero CE:
Numero MDL:
Codice UNSPSC:
12352202
ID PubChem:
NACRES:
NA.77
CHF 351.00
Spedizione prevista il30 maggio 2025
Prodotti consigliati
Origine biologica
synthetic (organic)
Saggio
≥98% (TLC)
Stato
powder
Solubilità
water: 25 mg/mL, clear, colorless
Temperatura di conservazione
2-8°C
Stringa SMILE
NC(=N)NO.NC(=N)NO.OS(O)(=O)=O
InChI
1S/2CH5N3O.H2O4S/c2*2-1(3)4-5;1-5(2,3)4/h2*5H,(H4,2,3,4);(H2,1,2,3,4)
MTGDDPZRXSDPFH-UHFFFAOYSA-N
Azioni biochim/fisiol
An early antitumor agent. Oxidation results in release of NO, and formation of other reactive oxygen species, including peroxynitrite and peroxyl radicals.[1] Reacts with NO to form an adduct which is a potent and stable vasodilator.
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Dispositivi di protezione individuale
Eyeshields, Gloves, type N95 (US)
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Amila Kahvedžić et al.
Journal of medicinal chemistry, 56(2), 451-459 (2012-12-21)
In this paper we report the synthesis of a new family of hydroxyguanidinium aromatic derivatives (4a-g) as potential minor groove binders and cytotoxic agents. Their DNA affinity was evaluated by thermal denaturation experiments using salmon sperm DNA. The antiproliferative effects
T Bill Cai et al.
Current topics in medicinal chemistry, 5(7), 721-736 (2005-08-17)
Nitric oxide (NO) has been implicated in a wide variety of disease states. Both inhibitors and substrates of nitric oxide synthase (NOS) could have great therapeutic potential in the treatment of these diseases. There is considerable pharmacological interest in developing
Kamil Brożewicz et al.
European journal of medicinal chemistry, 55, 384-394 (2012-08-16)
Twenty four 1-[2-alkylthio-5-(azol-2 or 5-yl)-4-chlorobenzenesulfonyl]-3-hydroxyguanidines 6a-x have been synthesized in order to evaluate their biological activity. Compounds 6a, 6c, 6d, 6f, 6g, 6i-p, 6r-t, and 6v-x were tested for their in vitro anticancer activity at the US National Cancer Institute. The
Zembowicz, A., et al.
British Journal of Pharmacology, 107, 1007-1007 (1992)
Rémy Ricoux et al.
European journal of biochemistry, 270(1), 47-55 (2002-12-21)
Nitric oxide (NO) is a potent intra- and intercellular messenger involved in the control of vascular tone, neuronal signalling and host response to infection. In mammals, NO is synthesized by oxidation of l-arginine catalysed by hemeproteins called NO-synthases with intermediate
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