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H0536

Sigma-Aldrich

Hepatocyte Growth Factor Receptor (c-Met)/Fc Chimera human

>95% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder

Sinonimo/i:

HGF Receptor (c-Met)

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About This Item

Numero MDL:
MFCD01867051
Codice UNSPSC:
12352202
NACRES:
NA.32

Origine biologica

human

Livello qualitativo

100

Ricombinante

expressed in NSO cells

Saggio

>95% (SDS-PAGE)

Forma fisica

lyophilized powder

Potenza

0.1-5 ng/mL

PM

calculated mol wt 129 kDa

Confezionamento

pkg of 100 μg

Condizioni di stoccaggio

avoid repeated freeze/thaw cycles

Impurezze

endotoxin, tested

N° accesso UniProt

P08581

Temperatura di conservazione

−20°C

Informazioni sul gene

human ... MET(4233)

Azioni biochim/fisiol

Heterodimeric transmembrane glycoprotein with binding capacity for c-Met. Activation of this receptor has been correlated with induction of the Ras pathway.

Altre note

Extracellular domain of c-Met fused to the C-terminal 6X histidine-tagged Fc region of human IgG1.

Stato fisico

Lyophilized from 0.2 μm filtered solution in phosphate buffered saline containing 5 mg bovine serum albumin.

Risultati analitici

The biological activity is measured by its ability to bind human HGF.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Yaroslava M Chalenko et al.
International journal of molecular sciences, 24(8) (2023-04-28)
Listeria monocytogenes virulence factor InlB specifically interacts with the receptors c-Met and gC1q-R. Both receptors are present in non-professional and professional phagocytes, including macrophages. Phylogenetically defined InlB isoforms differently support invasion into non-professional phagocytes. This work deals with the effects
Egor V Kalinin et al.
Drug development research, 82(1), 123-132 (2020-08-25)
Hepatocyte growth factor (HGF) is central to liver regeneration. The Internalin B (InlB) protein is a virulence factor produced by the pathogenic bacterium Listeria monocytogenes. InlB is known to mimic HGF activity by interacting with the HGF receptor (HGFR) and
M Park et al.
Proceedings of the National Academy of Sciences of the United States of America, 84(18), 6379-6383 (1987-09-01)
We isolated overlapping cDNA clones corresponding to the major MET protooncogene transcript. The cDNA nucleotide sequence contained an open reading frame of 1408 amino acids with features characteristic of the tyrosine kinase family of growth factor receptors. These features include
Xin Li et al.
Frontiers in cell and developmental biology, 9, 661122-661122 (2021-05-04)
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers with minimally effective treatments, highlighting the importance of developing novel biomarkers and therapeutic targets. Here, we disclosed the mechanisms that leukocyte cell-derived chemotaxin-2 (LECT2) modulates PDAC development using in

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