F4537
Fibroblast Growth Factor-5 human
recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture, ≥97% (SDS-PAGE and N-terminal analysis)
Sinonimo/i:
hFGF-5, FGF-5
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50 μG
CHF 455.00
CHF 455.00
Spedizione prevista il14 aprile 2025
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Cambia visualizzazione
50 μG
CHF 455.00
About This Item
CHF 455.00
Spedizione prevista il14 aprile 2025
Prodotti consigliati
Origine biologica
human
Livello qualitativo
Ricombinante
expressed in E. coli
Saggio
≥97% (SDS-PAGE and N-terminal analysis)
Stato
lyophilized powder
Potenza
0.1-15.0 ng/mL
PM
27 kDa
Confezionamento
pkg of 50 μg
Condizioni di stoccaggio
avoid repeated freeze/thaw cycles
tecniche
cell culture | mammalian: suitable
Impurezze
endotoxin, tested
N° accesso UniProt
Temperatura di conservazione
−20°C
Informazioni sul gene
human ... FGF5(2250)
Applicazioni
Fibroblast growth factor-5 human has been used for the induction of differentiation in E14Tg2a and 46C parental mouse ES (embryonic stem) cell lines, Fgf4+/- (clone 342) ,Fgf4-/- (clone FD6) ES cells and Erk2+/- ES cells and Erk2-/- ES cell lines.[1]
Azioni biochim/fisiol
FGF5 (fibroblast growth factor 5) regulates hair growth cycle, and its inactivation in mice leads to angora phenotype. In the peripheral nervous system, it acts as a muscle-derived trophic factor for motor neurons. In vivo it demonstrates neurotrophic activity, and in vitro it influences astroglial characteristics. It functions as an oncogene in glioblastoma due to its autocrine and paracrine functions. Its expression is elevated in human astrocytic brain tumours, which is linked to increased malignancy.[2] It causes the regression of hair follicles, and thus, controls the length of hair in humans. It might have potential as a therapeutic target to control the growth of eyelashes.[3]
Stato fisico
Lyophilized from a 0.2 μm filtered solution in 10mM MOPS, 50 mM NaSO4, 0.5 mM EDTA, 0.5 mM DTT and 5% trehalose, pH 7.0 containing 50 μg BSA per 1 μg cytokine.
Risultati analitici
The biological activity is tested in culture with quiescent NR6R-3T3 fibroblasts.[4]
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 2
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Dispositivi di protezione individuale
Eyeshields, Gloves, type N95 (US)
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Claire A Higgins et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(29), 10648-10653 (2014-07-06)
Mechanisms that regulate the growth of eyelashes have remained obscure. We ascertained two families from Pakistan who presented with familial trichomegaly, or extreme eyelash growth. Using a combination of whole exome sequencing and homozygosity mapping, we identified distinct pathogenic mutations
S Allerstorfer et al.
Oncogene, 27(30), 4180-4190 (2008-03-26)
Fibroblast growth factor 5 (FGF5) is widely expressed in embryonic but scarcely in adult tissues. Here we report simultaneous overexpression of FGF5 and its predominant high-affinity receptor (FGFR1 IIIc) in astrocytic brain tumour specimens (N=49) and cell cultures (N=49). The
Fibroblast growth factors (FGFs).
Vainikka, S., et al. et al.
Guidebook to Cytokines and Their Receptors, 214-214 (1994)
M Klagsbrun
Progress in growth factor research, 1(4), 207-235 (1989-01-01)
This article summarizes the structural and biological properties of the family of fibroblast growth factors (FGF). Basic FGF (bFGF) and acidic FGF (aFGF) are the best characterized members of this family. bFGF and aFGF are potent modulators of cell proliferation
Ahlam I Salameh et al.
The Journal of physiology, 595(1), 93-124 (2016-06-30)
A polymorphism of human AE3 is associated with idiopathic generalized epilepsy. Knockout of AE3 in mice lowers the threshold for triggering epileptic seizures. The explanations for these effects are elusive. Comparisons of cells from wild-type vs. AE3 The anion exchanger
Articoli
Fibroblast growth factors in cell culture and various growth factors for your research
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