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F3680

Sigma-Aldrich

10058-F4

≥98% (HPLC), solid

Sinonimo/i:

5-[(4-Ethylphenyl)methylene]-2-thioxo-4-thiazolidinone

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5 MG
CHF 77.40
25 MG
CHF 309.00

CHF 77.40

Spedizione prevista il02 giugno 2025

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Cambia visualizzazione
5 MG
CHF 77.40
25 MG
CHF 309.00

About This Item

Formula empirica (notazione di Hill):
C12H11NOS2
Numero CAS:
403811-55-2
Peso molecolare:
249.35
Numero MDL:
MFCD00758517
Codice UNSPSC:
12352200
ID PubChem:
329799701
NACRES:
NA.77

CHF 77.40

Spedizione prevista il02 giugno 2025

Richiedi un ordine bulk

Livello qualitativo

100

Saggio

≥98% (HPLC)

Stato

solid

Colore

yellow

Solubilità

DMSO: >10 mg/mL
H2O: <2 mg/mL

Temperatura di conservazione

2-8°C

Stringa SMILE

CCc1ccc(cc1)\C=C2\SC(=S)NC2=O

InChI

1S/C12H11NOS2/c1-2-8-3-5-9(6-4-8)7-10-11(14)13-12(15)16-10/h3-7H,2H2,1H3,(H,13,14,15)/b10-7+
SVXDHPADAXBMFB-JXMROGBWSA-N

Applicazioni

10058-F4 has been used:
  • as c-Myc inhibitor to treat stromal cells[1]
  • as c-Myc inhibitor to determine the effect of c-Myc inhibition on cardiac progenitor cells (CPC) growth[2]
  • as c-Myc inhibitor to culture T cells[3]
  • to treat C4-2 cells to examine the activity of MST1 promoter luciferase reporter construct[4]

Azioni biochim/fisiol

10058-F4 is a c-Myc inhibitor that induces cell-cycle arrest and apoptosis. 10058-F4 is a cell-permeable thiazolidinone that specificallly inhibits the c-Myc-Max interaction and prevents transactivation of c-Myc target gene expression. 10058-F4 inhibits tumor cell growth in a c-Myc-dependent manner both in vitro and in vivo (64 μM using c-Myc transfected Rat1a fibroblasts).
10058-F4 is a c-Myc inhibitor.

Caratteristiche e vantaggi

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Pittogrammi

Exclamation mark
GHS07

Avvertenze

Warning

Indicazioni di pericolo

H317,H319

Classi di pericolo

Eye Irrit. 2 - Skin Sens. 1

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificati d'analisi (COA)

Lot/Batch Number
0000191112
0000191113
094M4601V
092M4635V

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Dimetil solfossido

Overexpression of MYC and EZH2 cooperates to epigenetically silence MST1 expression
Kuser-Abali G, et al.
Epigenetics, 9(4), 634-643 (2014)
Camilla U Persson et al.
Scientific reports, 7(1), 10274-10274 (2017-09-02)
Cultured cancer cells serve as important models for preclinical testing of anti-cancer compounds. However, the optimal conditions for retaining original tumor features during in vitro culturing of cancer cells have not been investigated in detail. Here we show that serum-free
cMyc-p53 feedback mechanism regulates the dynamics of T lymphocytes in the immune response
Madapura HS, et al.
Cell Cycle, 15(9), 1267-1275 (2016)
Hypoxic Stress Decreases c-Myc Protein Stability in Cardiac Progenitor Cells Inducing Quiescence and Compromising Their Proliferative and Vasculogenic Potential
Bellio MA, et al.
Scientific reports, 7(1), 9702-9702 (2017)
Bethany C Prudner et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 25(16), 5122-5134 (2019-05-23)
The response to acute and long-term arginine starvation results in a conditional adaptive metabolic reprogramming that can be harnessed for therapeutic opportunities in ASS1-negative tumors. Here, we investigate the underlying biology of priming ASS1- tumors with arginine deiminase (ADI-PEG20) before
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