F3388

Ferric citrate

BioReagent, suitable for cell culture

• Sinonimo/i: Iron(III) citrate, Iron(III) citrate hydrate
• Formula empirica (notazione di Hill): C₆H₅FeO₇
• Numero CAS: 3522-50-7
• Peso molecolare: 244.94
• NACRES: NA.75
• PubChem Substance ID: 24894843
• UNSPSC Code: 12352205
• EC Number: 222-536-6
• MDL number: MFCD00013098

Proprietà

• biological source: synthetic (organic)
• Quality Segment: 300
• product line: BioReagent
• technique(s): cell culture | mammalian: suitable
• solubility: hot water: 0.01 g/mL, clear, orange-yellow
• shipped in: ambient
• storage temp.: room temp
• SMILES string: OC12CC(=O)O[Fe](OC(=O)C1)OC2=O
• InChI: 1S/C6H8O7.Fe/c7-3(8)1-6(13,5(11)12)2-4(9)10;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);/q;+3/p-3
• InChI key: NPFOYSMITVOQOS-UHFFFAOYSA-K

Descrizione

Application

Ferric citrate provides a source of iron used in cell culture applications. It provides iron in a less toxic form than free iron salts. Ferric citrate has been used as medium supplement in human osteosarcoma cell (U2OS) culture, human embryonic kidney (HEK293) cells and adult primary cardiomyocytes.

Biochem/physiol Actions

Ferric citrate is used as a component of protein-free medium. It is used as a substitute for transferrin in mouse hybridomas culture. Ferric citrate enhances IgM production. It indirectly stimulates the mitogen-activated protein kinase (MAPK) by favoring high amphiregulin oncoprotein levels in colon cancer.  Ferric citrate is effective in binding to phosphate in patients with dialysis-dependent chronic kidney disease.

Informazioni sulla sicurezza

• Classe di stoccaggio: 11 - Combustible Solids
• wgk: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)