A sterile 2% aqueous solution of product is reported to be stable for up to 2 weeks at 2–8 °C, protected from light. Long-term stability at -20 °C is not established for this product, although an external source suggests potential stability for up to 6 months at -20 °C. This information has not been validated.
Please see the link below to review additional information available in the product datasheet:
https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/716/505/f0503pis.pdf
F0503
5-Fluoro-2′-deoxyuridine
thymidylate synthase inhibitor
Sinonimo/i:
floxuridine, 2′-Deoxy-5-fluorouridine, FUDR, Floxuridine
Autenticati per visualizzare i prezzi organizzativi e contrattuali.
Scegli un formato
Cambia visualizzazione
| Voi/SKU | Disponibilità | Prezzo |
|---|---|---|
100 mg | Per conoscere la disponibilità, visualizza il carrello | CHF 355.00 |
250 mg | Per conoscere la disponibilità, visualizza il carrello | CHF 803.00 |
1 g | Per conoscere la disponibilità, visualizza il carrello | CHF 2040.00 |
Informazioni su questo articolo
Formula empirica (notazione di Hill):
C9H11FN2O5
Numero CAS:
Peso molecolare:
246.19
NACRES:
NA.77
PubChem Substance ID:
EC Number:
200-072-5
Beilstein/REAXYS Number:
90221
MDL number:
UNSPSC Code:
12352208
Servizio Tecnico
Hai bisogno di aiuto? Il nostro team di scienziati qualificati è a tua disposizione.
Permettici di aiutartibiological source
synthetic (organic)
Quality Segment
assay
≥99% (HPLC)
form
powder
mp
148 °C (lit.)
solubility
water: 50 mg/mL, clear, colorless to faintly yellow
storage temp.
room temp
SMILES string
OC[C@H]1O[C@H](C[C@@H]1O)N2C=C(F)C(=O)NC2=O
InChI
1S/C9H11FN2O5/c10-4-2-12(9(16)11-8(4)15)7-1-5(14)6(3-13)17-7/h2,5-7,13-14H,1,3H2,(H,11,15,16)/t5-,6+,7+/m0/s1
InChI key
ODKNJVUHOIMIIZ-RRKCRQDMSA-N
Gene Information
human ... TYMS(7298)
mouse ... Tyms(22171)
General description
5-Fluoro-2′-deoxyuridine, also called floxuridine elicits DNA-directed cytotoxicity in cancer cells. Floxuridine is effective for treating liver cancer and eliminating virulence of Staphylococcus aureus. Dipeptide prodrugs combination of floxuridine with gemcitabine are more cell permeable and display enhanced anti-proliferative activity. Floxuridine is effective on solid tumours and advanced stage cancers.
Application
5-Fluoro-2′-deoxyuridine has been used as a mitotic inhibitor in schwann cell proliferation, glia proliferation and nonneuronal cells in dorsal root ganglion cultures.
Biochem/physiol Actions
Antineoplastic drug that acts as a potent inhibitor of thymidylate synthetase Resistance to FUdR can develop in cancer cell cultures, among other means, by low-level Mycoplasma infection.
1 of 1
Questo articolo | |||
|---|---|---|---|
| description thymidylate synthase inhibitor | description Experimental anticancer agent shown to have activity against a variety of malignant neoplasms, including mouse mammary tumors and colorectal carcinomas. | description United States Pharmacopeia (USP) Reference Standard | description pharmaceutical secondary standard, certified reference material |
| biological source synthetic (organic) | biological source - | biological source - | biological source - |
| assay ≥99% (HPLC) | assay ≥98% (HPLC) | assay - | assay - |
| Gene Information human ... TYMS(7298) | Gene Information - | Gene Information human ... TYMS(7298) | Gene Information - |
| Quality Level 200 | Quality Level 100 | Quality Level - | Quality Level 300 |
| form powder | form solid | form - | form powder |
| solubility water: 50 mg/mL, clear, colorless to faintly yellow | solubility water: 1 mg/mL, aqueous buffer: 1 mg/mL | solubility - | solubility - |
Still not finding the right product?
Explore all of our products under 5-Fluoro-2′-deoxyuridine
Parola di avvertenza
Danger
Codici di pericolo
Avvertenze di sicurezza
Hazard Classifications
Acute Tox. 3 Oral
Classe di stoccaggio
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
Che succede?
WGK 3
Punto di infiammabilità (°F)
Not applicable
Punto di infiammabilità (°C)
Not applicable
DPI (dispositivi di protezione individuale)
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Scegli una delle versioni più recenti:
Possiedi già questo prodotto?
I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.
-
Once I reconstitute this product in water, can I store it long term?
1 answer-
Helpful?
-
-
Is it possible to sterile filter (0.2 mikrometer) this compound for safer use in cell culture?
1 answer-
This product is soluble in water at 50 mg/mL. Solutions may be filter sterilized and are stable for 2 weeks at 2-8 °C. Solutions should be protected from light.
See the link below to review the product datasheet:
https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/716/505/f0503pis.pdfHelpful?
-