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This product is soluble in water at 50 mg/mL. Solutions may be filter sterilized and are stable for 2 weeks at 2-8 °C. Solutions should be protected from light.
See the link below to review the product datasheet:
https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/716/505/f0503pis.pdf
F0503
5-Fluoro-2′-deoxyuridine
thymidylate synthase inhibitor
Sinonimo/i:
floxuridine, 2′-Deoxy-5-fluorouridine, FUDR, Floxuridine
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100 MG
CHF 341.00
250 MG
CHF 771.00
1 G
CHF 1’960.00
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Cambia visualizzazione
100 MG
CHF 341.00
250 MG
CHF 771.00
1 G
CHF 1’960.00
About This Item
Formula empirica (notazione di Hill):
C9H11FN2O5
Numero CAS:
Peso molecolare:
246.19
Beilstein:
90221
Numero CE:
Numero MDL:
Codice UNSPSC:
12352202
ID PubChem:
NACRES:
NA.77
Prodotti consigliati
Origine biologica
synthetic (organic)
Saggio
≥99% (HPLC)
Stato
powder
Punto di fusione
148 °C (lit.)
Solubilità
water: 50 mg/mL, clear, colorless to faintly yellow
Temperatura di conservazione
room temp
Stringa SMILE
OC[C@H]1O[C@H](C[C@@H]1O)N2C=C(F)C(=O)NC2=O
InChI
1S/C9H11FN2O5/c10-4-2-12(9(16)11-8(4)15)7-1-5(14)6(3-13)17-7/h2,5-7,13-14H,1,3H2,(H,11,15,16)/t5-,6+,7+/m0/s1
ODKNJVUHOIMIIZ-RRKCRQDMSA-N
Informazioni sul gene
human ... TYMS(7298)
mouse ... Tyms(22171)
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Descrizione generale
5-Fluoro-2′-deoxyuridine, also called floxuridine elicits DNA-directed cytotoxicity in cancer cells.[1] Floxuridine is effective for treating liver cancer[2] and eliminating virulence of Staphylococcus aureus.[3] Dipeptide prodrugs combination of floxuridine with gemcitabine are more cell permeable and display enhanced anti-proliferative activity.[4] Floxuridine is effective on solid tumours and advanced stage cancers.[5]
Applicazioni
Azioni biochim/fisiol
Antineoplastic drug that acts as a potent inhibitor of thymidylate synthetase Resistance to FUdR can develop in cancer cell cultures, among other means, by low-level Mycoplasma infection.
Avvertenze
Danger
Indicazioni di pericolo
Consigli di prudenza
Classi di pericolo
Acute Tox. 3 Oral
Codice della classe di stoccaggio
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Dispositivi di protezione individuale
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
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Is it possible to sterile filter (0.2 mikrometer) this compound for safer use in cell culture?
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