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E4644

Sigma-Aldrich

Anti-Erythropoietin Receptor antibody produced in goat

affinity isolated antibody

Sinonimo/i:

Anti-EPO R

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About This Item

Codice UNSPSC:
51111800
ID PubChem:
NACRES:
NA.41

Origine biologica

goat

Livello qualitativo

Coniugato

unconjugated

Forma dell’anticorpo

affinity isolated antibody

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Reattività contro le specie

human

tecniche

western blot: 1 μg/mL

N° accesso UniProt

Temperatura di conservazione

−20°C

modifica post-traduzionali bersaglio

unmodified

Stringa SMILE

CCCCCCCC/C=C/CCCCCCCCCC(OC(CCCCCCCC/C=C/CCCCCCCCC)=O)=O

InChI

1S/C40H74O3/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-35-37-39(41)43-40(42)38-36-34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h17,19-20,22H,3-16,18,21,23-38H2,1-2H3/b19-17+,22-20+
WOPZJDCVLPFUEY-ZEYSCXRRSA-N

Informazioni sul gene

human ... EPOR(2057)

Descrizione generale

Erythropoietin Receptor (EPO R) is a protein that belongs to type I cytokine receptor superfamily and is expressed mainly in megakaryocytes, erythoid progenitors, endothelial cells and neurons. Erythropoietin binds to EPO receptor and stimulates Jak2 tyrosine kinase which in turn phosphorylate tyrosine residue of EPO receptor and results in activation of several intracellular pathways (Ras/MAP kinase, phosphatidylinositol 3-kinase, and STAT transcription factors). Anti-Erythropoietin Receptor antibody can be used for analyzing the neurite outgrowth. Goat anti-Erythropoietin Receptor antibody reacts specifically with recombinant human erythropoietin receptor.

Immunogeno

recombinant human erythropoietin soluble receptor, expressed in NSO cells.

Applicazioni

Anti-Erythropoietin Receptor can be used in western blotting at a working antibody concentration of 1 μg/ml for detecting human EPO receptor.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunocytochemistry (1 paper)

Stato fisico

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 5% trehalose.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Prodotti correlati

Codice della classe di stoccaggio

13 - Non Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable


Certificati d'analisi (COA)

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María José Vázquez-Mellado et al.
Oncology reports, 41(2), 1333-1341 (2018-11-30)
Erythropoietin (Epo) is used for the treatment of cancer‑associated anaemia. However, certain studies have identified that the administration of Epo mediates the acquisition of resistance to cisplatin, which is widely used to treat cervical cancer. Our group previously reported that
Structure, function, and activation of the erythropoietin receptor.
H Youssoufian et al.
Blood, 81(9), 2223-2236 (1993-05-01)
The erythropoietin receptor and the molecular basis of signal transduction.
D L Barber et al.
Seminars in hematology, 29(4), 293-304 (1992-10-01)
Stanislava Pankratova et al.
Journal of neurochemistry, 121(6), 915-923 (2012-04-04)
Apart from its hematopoietic activity, erythropoietin (EPO) is also known as a tissue-protective cytokine. In the brain, EPO and its receptor are up-regulated in response to insult and exert pro-survival effects. EPO binds to its receptor (EPOR) via high- and
S Y Lam et al.
Advances in experimental medicine and biology, 648, 207-214 (2009-06-19)
The carotid body (CB) plays important roles in cardiorespiratory changes in intermittent hypoxia (IH). Erythropoietin (EPO), a hypoxia-inducible factor (HIF)-1 target gene, is present in the chemoreceptive type-I cells in the CB but its expression and role in IH resembling

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