Selective phosphodiesterase III (PDE3) inhibitor. Prevents the degradation of cAMP by PDE.
Selective phosphodiesterase III (PDE3) inhibitor. Prevents the degradation of cAMP by PDE. Increased cAMP results in enhanced contractility of the heart.
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Basic research in cardiology, 105(2), 155-167 (2009-10-21)
Reperfusion injury is strongly involved in the loss of functional heart tissue in patients after acute myocardial infarction. Various signal transduction pathways to reduce infarct size during reperfusion have been characterized. However, so far in the clinical setting no standard
Veterinary anaesthesia and analgesia, 36(2), 101-109 (2009-02-26)
To investigate the influence of calcium chloride (CaCl(2)) on the cardio-respiratory effects of enoximone in isoflurane anaesthetized ponies. Prospective consecutive experimental trial. Animals Six healthy ponies, weighing 287 +/- 55 kg were included in this study. After sedation (romifidine, 80
Enoximone is an imidazolone derivative currently undergoing trials in patients with congestive heart failure refractory to conventional therapy. It is a phosphodiesterase inhibitor with both positive inotropic and vasodilator properties, and is active by both oral and intravenous routes of
European heart journal, 30(24), 3015-3026 (2009-08-25)
Use of inotropic agents in patients with heart failure (HF) has been limited by adverse effects on outcomes. However, administration of positive inotropes at lower doses and concomitant treatment with beta-blockers might increase benefit-risk ratio. We investigated the effects of
Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.
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