D9439

Desmosine chloride

from bovine, 99.5%±0.2%

• Sinonimo/i: DES
• Formula empirica (notazione di Hill): C₂₄H₄₀ClN₅O₈
• Numero CAS: 10019-68-8
• Peso molecolare: 562.06
• Numero MDL: MFCD12910449
• Codice UNSPSC: 12352202
• ID PubChem: 329798901
• NACRES: NA.56

Proprietà

• Origine biologica: bovine
• Livello qualitativo: 100
• Saggio: 99.5%±0.2%
• Stato: lyophilized powder
• Purificato mediante: chromatography (and purified by solvent extraction)
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: [Cl-].NC(CCCC[n+]1cc(CCC(N)C(O)=O)c(CCCC(N)C(O)=O)c(CCC(N)C(O)=O)c1)C(O)=O
• InChI: 1S/C24H39N5O8.ClH/c25-17(21(30)31)5-1-2-11-29-12-14(7-9-19(27)23(34)35)16(4-3-6-18(26)22(32)33)15(13-29)8-10-20(28)24(36)37;/h12-13,17-20H,1-11,25-28H2,(H3-,30,31,32,33,34,35,36,37);1H; FUPMLZCXPJSGPV-UHFFFAOYSA-N

Descrizione

Descrizione generale

Each vial contains 1 μmole of purified desmosine.

Applicazioni

Assays for free or urinary desmosine are often used as markers for disease states characterized by elastin degradation (e.g., emphysema). Conversely, excessive levels of incorporated desmosine are indicators of fibrotic conditions (e.g., cirrhosis).

Desmosine chloride is often used in assays for free or urinary desmosine as markers for disease states characterized by elastin degradation (e.g., emphysema). Elastin degradation has shown strong correlation with vascular calcification, and pretreatment with aluminum ions can inhibit the binding of matrix metalloproteinase (MMP) to elastin.

Azioni biochim/fisiol

Desmosine is a polyfunctional amino acid that forms cross-links in mature elastin.

Avvertenza

Extremely hygroscopic

Risultati analitici

Calibrated by UV and amino acid analysis.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, type N95 (US)