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D8440

15-Deoxy-Δ^12,14-prostaglandin J₂

Name: 15-Deoxy-Δ<SUP>12,14</SUP>-prostaglandin J<SUB>2</SUB>
Brand: SIGMA
Price: 42.9 CHF

≥95% (HPLC), 1 mg/mL in methyl acetate

Sinonimo/i:

11-Oxoprosta-(5Z,9,12E,14E)-tetraen-1-oic acid, 15-Deoxy-Δ12,14-PGJ₂

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A voi/SKU	Disponibilità	Prezzo
100 μg	Per conoscere la disponibilità, visualizza il carrello	CHF 42.90

Informazioni su questo articolo

Formula empirica (notazione di Hill):

C₂₀H₂₈O₃

Numero CAS:

87893-55-8

Peso molecolare:

316.43

NACRES:

NA.77

PubChem Substance ID:

329798863

UNSPSC Code:

12352211

EC Number:

201-185-2

MDL number:

MFCD00065806

Assay:

≥95% (HPLC)

Form:

liquid

CHF 42.90

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Proprietà

Quality Segment

200

assay

≥95% (HPLC)

form

liquid

concentration

1 mg/mL in methyl acetate

shipped in

wet ice

storage temp.

−20°C

SMILES string

CCCCC\C=C\C=C1/[C@@H](C\C=C/CCCC(O)=O)C=CC1=O

InChI

1S/C20H28O3/c1-2-3-4-5-6-10-13-18-17(15-16-19(18)21)12-9-7-8-11-14-20(22)23/h6-7,9-10,13,15-17H,2-5,8,11-12,14H2,1H3,(H,22,23)/b9-7-,10-6+,18-13+/t17-/m0/s1

InChI key

VHRUMKCAEVRUBK-GODQJPCRSA-N

Descrizione

General description

15-Deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2) is a prostaglandin J2 (PGJ2) metabolite and a naturally occurring derivative of prostaglandin D2. It is produced during inflammatory processes.

Application

15-Deoxy-Δ12,14-prostaglandin J2 has been used:

to study its effect on lipid accumulation, viability/mitochondrial activity, and amount of vasculature in vascularized adipose tissue model
as a peroxisome proliferator-activated receptor (PPARγ) agonist to activate intestinal fatty acid binding protein (I-FABP)-PPARγ pathway
as a supplement in culture medium for induced neural stem/progenitor cells (NSPCs) differentiation

Biochem/physiol Actions

15-Deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2) regulates inflammatory response in vivo. 15d-PGJ2 also elicits PPARγ-independent inhibition of nuclear factor (NF)-κB dependent transcription. It acts as an anti-angiogenic factor and triggers endothelial cell apoptosis.

Selective agonist to PPARγ (peroxisome proliferator-activated receptors). Inhibits the proliferation of cancer cell lines that express PPARγ and cyclooxygenase-2 (COX-2).

Disclaimer

Supply conditions do not apply to the regions and states of Brazil: North, Northeast, Mato Grosso do Sul, Mato Grosso, and Rio Grande do Sul.

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Questo articolo	538927	P5172	P5390
Sigma-Aldrich D8440 15-Deoxy-Δ^12,14-prostaglandin J₂	Sigma-Aldrich 538927 15d-PGJ₂	Sigma-Aldrich P5172 Prostaglandin D₂	Sigma-Aldrich P5390 Prostaglandin B₂
description ≥95% (HPLC), 1 mg/mL in methyl acetate	description A metabolite of PGD₂that has recently been identified as a natural ligand for PPARγ-dependent adipogenesis in transfected NIH/3T3 cells and for PPARγ response element (PPRE) in CV-1 cells.	description ≥95%, synthetic	description ≥98%, synthetic
form liquid	form oil	form powder	form solution
assay ≥95% (HPLC)	assay ≥95% (HPLC)	assay ≥95%	assay ≥98%
Quality Level 200	Quality Level 100	Quality Level 100	Quality Level 100
storage temp. −20°C	storage temp. −20°C	storage temp. −20°C	storage temp. −20°C
shipped in wet ice	shipped in wet ice	shipped in -	shipped in -
concentration 1 mg/mL in methyl acetate	concentration -	concentration -	concentration -

pictograms

GHS02,GHS07

signalword

Danger

hcodes

H225,H319,H336

pcodes

P210 - P233 - P240 - P241 - P242 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3

target_organs

Central nervous system

supp_hazards

EUH066

Classe di stoccaggio

3 - Flammable liquids

wgk

WGK 2

flash_point_f

15.8 °F - closed cup

flash_point_c

-9 °C - closed cup

ppe

Eyeshields, Faceshields, Gloves

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Certificati d'analisi (COA)

Lot/Batch Number

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