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D6513

Sigma-Aldrich

Desmosterol

≥84% (GC)

Sinonimo/i:

24-Dehydrocholesterol, 3β-Hydroxy-5,24-cholestadiene, 5,24-Cholestadien-3β-ol

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5 MG
CHF 77.40
10 MG
CHF 134.00

CHF 77.40

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5 MG
CHF 77.40
10 MG
CHF 134.00

About This Item

Formula empirica (notazione di Hill):
C27H44O
Numero CAS:
313-04-2
Peso molecolare:
384.64
Numero CE:
206-236-2
Numero MDL:
MFCD00056432
Codice UNSPSC:
12352200
ID PubChem:
24894033
NACRES:
NA.77

CHF 77.40

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Saggio

≥84% (GC)

Stato

powder

Temperatura di conservazione

−20°C

Stringa SMILE

[H][C@@]12[C@]([C@](CC[C@H](O)C3)(C)C3=CC2)([H])CC[C@@]4(C)[C@@]1([H])CC[C@]4([H])[C@]([H])(C)CCC=C(C)C

InChI

1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,9,19,21-25,28H,6,8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
AVSXSVCZWQODGV-DPAQBDIFSA-N

Descrizione generale

Desmosterol is a C27 sterol intermediate in cholesterol synthesis. It may be associated with the pathogenesis of Alzheimer′s disease (AD).[1]

Applicazioni

Desmosterol has been used as a standard for the estimation of the concentrations of cholesterol and plant sterols.[2][3] It has also been used to suppress nigericin-induced sterol regulatory element-binding proteins 2 (SREBP2) maturation.[4]

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

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Certificati d'analisi (COA)

Lot/Batch Number
0000406770
0000359254
0000356692
0000356690
0000324222

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Arjan Boerke et al.
Biology of reproduction, 88(1), 21-21 (2012-11-02)
This study demonstrates for the first time that porcine and mouse sperm incubated in capacitation media supplemented with bicarbonate produce oxysterols. The production is dependent on a reactive oxygen species (ROS) signaling pathway that is activated by bicarbonate and can
Clare L Beasley et al.
Bipolar disorders, 7(5), 449-455 (2005-09-24)
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Anna Meljon et al.
Journal of lipid research, 53(11), 2469-2483 (2012-08-15)
Unesterified cholesterol is a major component of plasma membranes. In the brain of the adult, it is mostly found in myelin sheaths, where it plays a major architectural role. In the newborn mouse, little myelination of neurons has occurred, and
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Cholesterol Biosynthesis

Cholesterol biosynthesis starts in the hepatic endoplasmic reticulum with acetyl-CoA, yielding 3-hydroxy-3-methylglutaryl-CoA via HMG-CoA synthase.

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