D3876

2′-Deoxyuridine 5′-monophosphate disodium salt

≥98% (HPLC), synthetic (organic), powder

• Sinonimo/i: dUMP
• Formula condensata: C₉H₁₁N₂O₈PNa₂
• Numero CAS: 42155-08-8
• Peso molecolare: 352.15
• NACRES: NA.51
• PubChem Substance ID: 24893787
• UNSPSC Code: 41106305
• EC Number: 255-687-1
• MDL number: MFCD00065282
• Assay: ≥98% (HPLC)
• Biological source: synthetic (organic)
• Form: powder
• Solubility: water: 50 mg/mL, clear, colorless
• Storage temp.: −20°C

Proprietà

• Nome del prodotto: 2′-Deoxyuridine 5′-monophosphate disodium salt, Sigma Grade
• biological source: synthetic (organic)
• Quality Segment: 200
• grade: Sigma Grade
• assay: ≥98% (HPLC)
• form: powder
• solubility: water: 50 mg/mL, clear, colorless
• storage temp.: −20°C
• SMILES string: [Na].OC1CC(OC1COP(O)(O)=O)N2C=CC(=O)NC2=O
• InChI: 1S/C9H13N2O8P.Na.H/c12-5-3-8(11-2-1-7(13)10-9(11)14)19-6(5)4-18-20(15,16)17;;/h1-2,5-6,8,12H,3-4H2,(H,10,13,14)(H2,15,16,17);;
• InChI key: WXIVKKBDJOCRNB-UHFFFAOYSA-N

Descrizione

General description

2′-Deoxyuridine 5′-monophosphate disodium salt (dUMP) is a substrate for thymidylate synthase and is converted to deoxythymidine monophosphate (dTMP).

Application

2′-Deoxyuridine 5′-monophosphate disodium salt has been used:

• in ultraperformance liquid chromatography-tandem mass spectrometry (UPLC/MS/MS) assay
• to stimulate proliferation of peripheral blood mononuclear cell (PBMCs) exposed to influenza virus antigen
• in thymidylate synthase activity assay Helicobacter pylori

2′-Deoxyuridine 5′-monophosphate (dUMP) is used by the enzyme thymidylate synthetase (TS) (EC 2.1.1.45) for the de novo production of dTMP. dUMP is used as the reference substrate in studies of dUMP analogues in potential chemotherapy applications.

Biochem/physiol Actions

2′-Deoxyuridine 5′-monophosphate disodium salt (dUMP) conversion to pyrimidine is inhibited by methotrexate. The inhibition of dUMP to deoxythymidine monophosphate (dTMP) at the methylation step is a key in controlling bacterial and eukaryotic cell growth.

Informazioni sulla sicurezza

• pictograms: GHS07
• signalword: Warning
• hcodes: H302,H315,H319,H335
• pcodes: P261 - P264 - P271 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Classe di stoccaggio: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves