Passa al contenuto
Merck

D129

R-(+)-DIOA

≥98% (HPLC), potassium/chloride (K+–Cl−) co-transporter inhibitor, solid

R-(+)-DIOA
1 of 1 reviewers received a sample product or took part in a promotion

Sinonimo/i:

R(+)-Butylindazone, R-(+)-[(2-n-Butyl-6,7-dichloro-2-cyclopentyl-2,3-dihydro-1-oxo-1H-inden-5-yl)oxy]acetic acid

Slide 1 of 1
Autenticati per visualizzare i prezzi organizzativi e contrattuali.

Scegli un formato

10 MG

CHF 318.00

50 MG

CHF 1’870.00

CHF 318.00

Per conoscere la disponibilità, visualizza il carrello
​
Richiedi un ordine in blocco

Informazioni su questo articolo

Formula empirica (notazione di Hill):
C20H24Cl2O4
Numero CAS:
81166-47-4
Peso molecolare:
399.31
UNSPSC Code:
12352200
PubChem Substance ID:
24277830
NACRES:
NA.77
MDL number:
MFCD00069261
Assay:
≥98% (HPLC)
Form:
solid
Quality level:
100

Documenti fondamentali

Visualizza tutta la documentazione

Vai a

Servizio Tecnico
Hai bisogno di aiuto? Il nostro team di scienziati qualificati è a tua disposizione.
Permettici di aiutarti

Nome del prodotto

R-(+)-DIOA, ≥98% (HPLC), solid

SMILES string

CCCC[C@]1(Cc2cc(OCC(O)=O)c(Cl)c(Cl)c2C1=O)C3CCCC3

InChI key

YAWWQIFONIPBKT-FQEVSTJZSA-N

InChI

1S/C20H24Cl2O4/c1-2-3-8-20(13-6-4-5-7-13)10-12-9-14(26-11-15(23)24)17(21)18(22)16(12)19(20)25/h9,13H,2-8,10-11H2,1H3,(H,23,24)/t20-/m0/s1

assay

≥98% (HPLC)

form

solid

optical activity

[α]27/D +18.1°, c = 0.7 in methanol(lit.)

color

white

solubility

H2O: insoluble <0.11 mg/mL, DMSO: >20 mg/mL, 0.1 M HCl: insoluble, 0.1 M NaOH: soluble, ethanol: soluble

Quality Level

100

Categorie correlate

Confronta articoli simili

Visualizza il confronto per intero

Mostra le differenze

1 of 4

Questo articolo
I117SML2692D122
R-(+)-DIOA &#8805;98% (HPLC), solid

Sigma-Aldrich

D129

R-(+)-DIOA

R(+)-IAA-94 &#8805;98% (HPLC), solid

Sigma-Aldrich

I117

R(+)-IAA-94

DCPIB &#8805;98% (HPLC)

Sigma-Aldrich

SML2692

DCPIB

Domperidone powder, &#8805;98% (HPLC)

Sigma-Aldrich

D122

Domperidone

form

solid

form

solid

form

powder

form

powder

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

-

Quality Level

100

solubility

H2O: insoluble <0.11 mg/mL, 0.1 M HCl: insoluble, ethanol: soluble, DMSO: >20 mg/mL, 0.1 M NaOH: soluble

solubility

H2O: 0.2 mg/mL, 0.1 M NaOH: 2.8 mg/mL, DMSO: >20 mg/mL, ethanol: 20 mg/mL, dilute aqueous acid: insoluble

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: >10 mg/mL, 0.1 M HCl: soluble, 0.1 M NaOH: slightly soluble, H2O: insoluble

color

white

color

white

color

white to beige

color

white

optical activity

[α]27/D +18.1°, c = 0.7 in methanol(lit.)

optical activity

[α]22/D +36.4°, c = 0.86 in methanol(lit.)

optical activity

-

optical activity

-

Application

R-(+)-DIOA has been used as a potassium/chloride K+-Cl- transport inhibitor to study its effects on:
  • short circuit current (Isc) in rat semicircular canal duct (SCCD) epithelium[1]
  • uptake of grepafloxacin by THP-1 monocytes[2]
  • the uptake of moxifloxacin by THP-1 monocytes[3]

Biochem/physiol Actions

[(dihydroindenyl)oxy]acetic acid (DIOA) acts as a potent inhibitor of potassium/chloride (K+–Cl−) co-transporter. It does not exert its effects on bumetanimide-sensitive [Na+,K+,Cl-]-cotransport system.[4]

Classe di stoccaggio

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Scegli una delle versioni più recenti:

Certificati d'analisi (COA)

Lot/Batch Number
0000523218
0000523218
0000515272
0000515272
0000504658

Non trovi la versione di tuo interesse?

Se hai bisogno di una versione specifica, puoi cercare il certificato tramite il numero di lotto.

Cerca un COA

Possiedi già questo prodotto?

I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.

Visita l’Archivio dei documenti

L D Ochoa-de la Paz et al.
Pflugers Archiv : European journal of physiology, 449(6), 526-536 (2005-01-05)
An increase in extracellular KCl ([KCl]o) occurs under various pathological conditions in the retina, leading to retinal swelling and possible neuronal damage. The mechanisms of this KCl o-induced retinal swelling were investigated in the present study, with emphasis on the
The inhibition of Na(+)-Pi cotransport and Pi self-exchange mechanisms in lactating rat mammary tissue.
J M Shillingford et al.
Biochemical Society transactions, 23(4), 559S-559S (1995-11-01)
Hikaru Nagao et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 30(3), 538-551 (2012-07-21)
Potassium chloride cotransporters (KCCs) mediate electroneutrally-coupled transport of K(+) and Cl(-), and play crucial roles in various cell functions including regulation of cell volume and homeostasis of cellular Cl(-)content. Four isoforms of KCCs (KCC1, 2, 3, and 4) have been
The relationship between volume-sensitive taurine efflux and the anion-exchanger in lactating mammary tissue.
D B Shennan et al.
Biochemical Society transactions, 23(2), 392S-392S (1995-05-01)
R P Garay et al.
Naunyn-Schmiedeberg's archives of pharmacology, 334(2), 202-209 (1986-10-01)
3-Amino-5-sulfamoylbenzoic acids and several series of (aryloxy)alkanoic acids were evaluated for their inhibitory effects on two human erythrocyte ion transport systems--the Na+,K+ cotransport system and the DIDS-sensitive anion carrier. Several classic loop diuretics, including the (aryloxy)alkanoic acid-ethacrynic acid and several
Visualizza tutti i documenti correlati
1 Review This action will navigate to reviews.

Questions

1 Review This action will navigate to reviews.
1 of 1 reviewers received a sample product or took part in a promotion

Reviews

Active Filters

  1. 1 Ratings-only review

Il team dei nostri ricercatori vanta grande esperienza in tutte le aree della ricerca quali Life Science, scienza dei materiali, sintesi chimica, cromatografia, discipline analitiche, ecc..

Contatta l'Assistenza Tecnica