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Merck
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Documenti fondamentali

C6499

Sigma-Aldrich

CTB

≥98% (HPLC)

Sinonimo/i:

CTPB, N-(4-Chloro-3-trifluoromethyl-phenyl)-2-ethoxy-benzamide

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About This Item

Formula empirica (notazione di Hill):
C16H13ClF3NO2
Numero CAS:
451491-47-7
Peso molecolare:
343.73
Numero MDL:
MFCD02356522
Codice UNSPSC:
12352200
NACRES:
NA.77

Saggio

≥98% (HPLC)

Stato

powder

Colore

white to off-white

Solubilità

DMSO: >10 mg/mL

Temperatura di conservazione

2-8°C

Stringa SMILE

FC(F)(F)c1c(ccc(c1)NC(=O)c2c(cccc2)OCC)Cl

InChI

YDXZSNHARVUYNM-UHFFFAOYSA-N

Descrizione generale

CTB (N-(4-Chloro-3-trifluoromethyl-phenyl)-2-ethoxy-benzamide) is derived from anacardic acid.

Applicazioni

CTB has been used to study its apoptotic effects on P53 protein acetylation.

Azioni biochim/fisiol

CBP (CREB binding protein)/p300) histone acetyltransferases (HATs) activator; p300 HAT activator.
CTPB was a first known small molecular activator of histone acetyltransferase p300. CTB is a simplified analog of CTPB with comparable or higher activity. The compound activates the histone acetyltransferase (HAT) activity of p300/EP300/E1A binding protein.
Small molecule activators of HAT such as CTB (N-(4-Chloro-3-trifluoromethyl-phenyl)-2-ethoxy-benzamide) is useful for altering chromatin acetylation directly. It might serve as a therapeutic agent for treating the complications of cognitive dysfunction including neuropsychiatric, neurodevelopmental and neurodegenerative diseases.

Caratteristiche e vantaggi

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 2

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Certificati d'analisi (COA)

Lot/Batch Number
0000139964
0000139964
0000188878
050M4611

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Willian S Korim et al.
Cardiovascular research, 115(6), 1092-1101 (2018-10-26)
Neuroinflammation is a common feature in renovascular, obesity-related, and angiotensin II mediated hypertension. There is evidence that increased release of the pro-inflammatory cytokine tumour necrosis factor-α (TNF-α) contributes to the development of the hypertension, but the underlying neural mechanisms are
The effect of CTB on P53 protein acetylation and consequence apoptosis on MCF-7 and MRC-5 cell lines
Dastjerdi MN, et al.
Advanced Biomedical Research, 2 (2013)
Cory Chew et al.
Neurorehabilitation and neural repair, 33(8), 656-667 (2019-07-10)
Background. Motoneuron loss is a severe medical problem that can result in loss of motor control and eventually death. We have previously demonstrated that partial motoneuron loss can result in dendritic atrophy and functional deficits in nearby surviving motoneurons, and
Franklin D Echevarria et al.
Frontiers in neuroscience, 11, 318-318 (2017-06-18)
The pleotropic cytokine interleukin-6 (IL-6) is implicated in retinal ganglion cell (RGC) survival and degeneration, including that associated with glaucoma. IL-6 protects RGCs from pressure-induced apoptosis
DeMetris D Reed et al.
Meat science, 123, 205-210 (2016-10-19)
Palatability attributes of beef striploin steaks mechanically enhanced with pork fat were evaluated. Striploins were collected from USDA Standard steer carcasses, longitudinally cut into halves (lateral or medial) and assigned randomly to pork fat injection (PFI) or non-injected control (CON).
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