C6013

Cholesteryl hemisuccinate tris salt

anionic detergent

• Sinonimo/i: 3β-Hydroxy-5-cholestene 3-hemisuccinate, 5-Cholesten-3β-ol 3-hemisuccinate, CHEMS, CHS, Cholesteryl hydrogen succinate
• Formula empirica (notazione di Hill): C₃₁H₅₀O₄ · C₄H₁₁NO₃
• Numero CAS: 102601-49-0
• Peso molecolare: 607.86
• UNSPSC Code: 12352211
• eCl@ss: 39023139
• PubChem Substance ID: 329775108
• NACRES: NA.77
• MDL number: MFCD00058298

Proprietà

• biological source: synthetic (organic)
• Quality Segment: 200
• assay: ≥98% (TLC)
• form: powder
• functional group: ester
• shipped in: ambient
• storage temp.: −20°C
• SMILES string: NC(CO)(CO)CO.CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@H](CC[C@]4(C)[C@H]3CC[C@]12C)OC(=O)CCC(O)=O
• InChI: 1S/C31H50O4.C4H11NO3/c1-20(2)7-6-8-21(3)25-11-12-26-24-10-9-22-19-23(35-29(34)14-13-28(32)33)15-17-30(22,4)27(24)16-18-31(25,26)5;5-4(1-6,2-7)3-8/h9,20-21,23-27H,6-8,10-19H2,1-5H3,(H,32,33);6-8H,1-3,5H2/t21-,23+,24+,25-,26+,27+,30+,31-;/m1./s1
• InChI key: SLDYONDUXRBLLR-XTCKSVDZSA-N

Descrizione

Application

Cholesteryl hemisuccinate tris salt has been used:

• to prepare solubilization buffer for glucan synthase assay
• to prepare immunoprecipitation buffer for immobilization of opioid receptors on paramagnetic beads.
• as a membrane stabilizer for liposomes and protein synaptogyrin-1
• as a component of a folate-modified self-microemulsifying drug delivery system.
• with N-dodecyl β-D-maltoside (DDM) to solubilize erythrocyte ghosts and chemokine receptor CCR1
• for protein solubilization

Biochem/physiol Actions

Cholesteryl hemisuccinate is an ionizable anionic detergent that stabilizes large unilamellar vesicles. These liposome vesicles act as delivery agents for anticancer drugs, oligonucleotides and antibiotics. Cholesteryl succinate also reportedly exhibits antiproliferative activity and may be clinically useful as antitumor agent.

Preparation Note

Cholesteryl hemisuccinate tris salt yields clear, colorless solution in methanol at 10 mg/ml.

Informazioni sulla sicurezza

• Classe di stoccaggio: 11 - Combustible Solids
• Che succede?: WGK 3
• Punto di infiammabilità (°F): Not applicable
• Punto di infiammabilità (°C): Not applicable