The solution stability of this product has not been determined. However, an identical product, 219557, notes that solutions prepared in organic solvents, such as acetone, may be stored protected from light at -20°C for up to 3 months. It is recommended that aqueous solutions not be stored for more than 1 day.
C2389
Cerulenin
from Cephalosporium caerulens, ≥98% (HPLC), powder, de novo phospholipid synthesis inhibitor
Sinonimo/i:
Helicocerin, (2R,3S,E,E)-2,3-Epoxy-4-oxo-7,10-dodecadienamide
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Cambia visualizzazione
| Voi/SKU | Disponibilità | Prezzo |
|---|---|---|
5 mg | Per conoscere la disponibilità, visualizza il carrello | CHF 328.00 |
10 mg | Per conoscere la disponibilità, visualizza il carrello | CHF 349.00 CHF 296.65 |
50 mg | Per conoscere la disponibilità, visualizza il carrello | CHF 1210.00 |
Informazioni su questo articolo
Formula empirica (notazione di Hill):
C12H17NO3
Numero CAS:
Peso molecolare:
223.27
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
51111800
EC Number:
241-424-8
MDL number:
Beilstein/REAXYS Number:
4140423
Assay:
≥98% (HPLC)
Form:
powder
Servizio Tecnico
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Permettici di aiutartiNome del prodotto
Cerulenin, ≥98% (HPLC), from Cephalosporium caerulens
biological source
Cephalosporium caerulens
Quality Segment
assay
≥98% (HPLC)
form
powder
mp
93 °C
solubility
acetone: 19.60-20.40 mg/mL, clear to slightly hazy, colorless to yellow
antibiotic activity spectrum
fungi
mode of action
enzyme | inhibits
storage temp.
−20°C
SMILES string
C/C=C/C/C=C/CCC([C@@H]1[C@H](C(N)=O)O1)=O
InChI
1S/C13H18O3/c1-3-4-5-6-7-8-9-11(15)13-12(16-13)10(2)14/h3-4,6-7,12-13H,5,8-9H2,1-2H3/b4-3+,7-6+/t12-,13+/m0/s1
InChI key
PTNNGEBMCNMENY-JIVMHGEESA-N
Gene Information
human ... FASN(2194)
General description
Cerulenin, an inhibitor of de novo phospholipid synthesis triggers apoptosis in various wild type p53 and mutant p53 tumor cell lines. This fungal antibiotic also blocks the condensing enzyme involved in fatty acid and polyketide biosynthesis.
Application
Cerulenin has been used:
- as a fatty acid synthase inhibitor to study its effects on aldosterone-induced trained immunity
- as a blocker of fatty acid synthase to study its effects on the replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV2)
- as a supplement in yeast extract–peptone–dextrose/glycerol (YPD/G) agar plates for the isolation of cerulenin-resistant yeast strains
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Questo articolo | |||
|---|---|---|---|
| description ≥98% (HPLC), from Cephalosporium caerulens | description from Taxus brevifolia, ≥95% (HPLC), powder | description synthetic | description - |
| form powder | form powder | form powder | form powder |
| assay ≥98% (HPLC) | assay ≥95% (HPLC) | assay - | assay - |
| Quality Level 200 | Quality Level 200 | Quality Level 200 | Quality Level 200 |
| storage temp. −20°C | storage temp. 2-8°C | storage temp. −20°C | storage temp. −20°C |
| solubility acetone: 19.60-20.40 mg/mL, clear to slightly hazy, colorless to yellow | solubility methanol: soluble 50 mg/mL, clear, colorless (undergoes transesterification), DMSO: 50 mg/mL (can be stored frozen for several months) | solubility water: 50 mg/mL, clear, colorless to light yellow | solubility - |
| Gene Information human ... FASN(2194) | Gene Information human ... BCL2(596), TUBA1A(7846), TUBA1B(10376), TUBA1C(84790), TUBA3C(7278), TUBA3E(112714), TUBA4A(7277), TUBB(203068), TUBB1(81027), TUBB2A(7280), TUBB2B(347733), TUBB3(10381), TUBB4A(10382), TUBB4B(10383), TUBB6(84617), TUBB8(347688) | Gene Information human ... GRIN1(2902), GRIN2A(2903), GRIN2B(2904), GRIN2C(2905), GRIN2D(2906), GRINA(2907) | Gene Information human ... GRIN1(2902), GRIN2A(2903), GRIN2B(2904), GRIN2C(2905), GRIN2D(2906), GRIN3A(116443), GRIN3B(116444), GRINA(2907) |
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HOW LONG IS CERULENIN STABLE FOR WHEN DISSOLVED IN ACETONE?
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