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C1230

Sigma-Aldrich

Z-Ile-Glu(O-ME)-Thr-Asp(O-Me) fluoromethyl ketone

≥90% (TLC), powder

Sinonimo/i:

Z-IETD-FMK

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About This Item

Formula empirica (notazione di Hill):
C30H43FN4O11
Numero CAS:
220760-26-9
Peso molecolare:
654.68
Numero MDL:
MFCD01861686
Codice UNSPSC:
12352209
ID PubChem:
329774744
NACRES:
NA.77

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Origine biologica

synthetic (organic)

Livello qualitativo

200

Saggio

≥90% (TLC)

Stato

powder

Solubilità

methanol: 10 mg/mL
DMSO: 20 mM, clear, colorless to light yellow

Condizioni di spedizione

dry ice

Temperatura di conservazione

−20°C

Stringa SMILE

CC[C@H](C)[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)O)C(=O)N[C@@H](CC(O)=O)C(=O)CF

InChI

1S/C28H39FN4O11/c1-4-15(2)23(33-28(43)44-14-17-8-6-5-7-9-17)26(41)30-18(10-11-21(36)37)25(40)32-24(16(3)34)27(42)31-19(12-22(38)39)20(35)13-29/h5-9,15-16,18-19,23-24,34H,4,10-14H2,1-3H3,(H,30,41)(H,31,42)(H,32,40)(H,33,43)(H,36,37)(H,38,39)/t15-,16+,18-,19-,23-,24-/m0/s1
CTXDBLYOEUERAT-VUVYEONESA-N

Amino Acid Sequence

Z-Ile-Glu-OMe-Thr-Asp-OMe-FMK

Applicazioni

Z-Ile-Glu(O-ME)-Thr-Asp(O-Me) fluoromethyl ketone (Z-IETD-FMK) has been used as a caspase-8 inhibitor:
  • to study the activity of caspase-8 in porcine kidney cells[1]
  • to study its effects on porcine parvovirus (PPV)-induced caspase-3 activity in steroidogenic luteal cells[2]
  • to study its effects on retinal ganglion and astroglia in rat eyes[3]

Azioni biochim/fisiol

Z-Ile-Glu(O-ME)-Thr-Asp(O-Me) fluoromethyl ketone (Z-IETD-FMK) is an irreversible and cell-permeable caspase-8 inhibitor.[4]

Caratteristiche e vantaggi

This compound is featured on the Caspases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

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Certificati d'analisi (COA)

Lot/Batch Number
SLCG0101
SLCC0510
SLBW7929
SLBV1990
SLBS2430V

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