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C0493

Sigma-Aldrich

Monoclonal Anti-Calcium Sensing Receptor

clone HL1499 (6D4-3F4-6C4), purified from hybridoma cell culture

Sinonimo/i:

Anti-CAR, Anti-EIG8, Anti-FHH, Anti-FIH, Anti-GPRC2A, Anti-HHC, Anti-HHC1, Anti-HYPOC1, Anti-NSHPT, Anti-PCAR1, Anti-hCasR

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About This Item

Numero MDL:
Codice UNSPSC:
12352203
NACRES:
NA.41

Origine biologica

mouse

Livello qualitativo

Coniugato

unconjugated

Forma dell’anticorpo

purified immunoglobulin

Tipo di anticorpo

primary antibodies

Clone

HL1499 (6D4-3F4-6C4), monoclonal

Forma fisica

buffered aqueous solution

Reattività contro le specie

rabbit, rat, mouse, human

tecniche

immunocytochemistry: suitable
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
indirect ELISA: suitable
western blot: 3-6 μg/mL using total extract from rat kidney

Isotipo

IgG1

N° accesso UniProt

Condizioni di spedizione

dry ice

Temperatura di conservazione

−20°C

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... CASR(846)
mouse ... Casr(12374)
rat ... Casr(24247)

Categorie correlate

Descrizione generale

The calcium sensing receptor (CASR) gene with 11 exons is mapped to human chromosome 3q13.33-q21.1. CASR is a member of the C family of G protein–coupled receptors and is mainly localized in the parathyroid gland and the thick ascending limb of the Henle loop. CASR is a 1078 amino acid protein.

Immunogeno

peptide corresponding to amino-acids 15-29 at the extracellular N-terminus of calcium sensing receptor.

Applicazioni

Monoclonal Anti-Calcium Sensing Receptor antibody produced in mouse is suitable for the following applications:
  • Indirect ELISA
  • Immunoblotting
  • Immunocytochemistry
  • Immunohistochemistry (formalin-fixed, paraffin-embedded sections)
  • Western blotting at a concentration of 3-6μg/mL using total extract from rat kidney
Monoclonal anti-calcium sensing receptor antibody produced in mouse has been used in western blotting and immunohistochemistry.

Azioni biochim/fisiol

Calcium sensing receptor (CASR) regulates cell activity according to the extracellular calcium concentration. It also plays a major role in controlling parathyroid hormone (PTH) secretion. Thus, this protein can be considered as a potent target for therapeutic agents designed to modify parathyroid gland function. CASR has a role in key signal transduction pathways in several tissues such as parathyroid gland, kidney, gastrointestinal tract, placenta, pancreas and brain. Mutation in the gene is associated with autosomal dominant hypocalcemic, hypercalciuria and Bartter syndrome.

Stato fisico

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

12 - Non Combustible Liquids

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable


Certificati d'analisi (COA)

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Increased Calcium-Sensing Receptor Immunoreactivity in the Hippocampus of a Triple Transgenic Mouse Model of Alzheimer's Disease
Gardenal E, et al.
Frontiers in Neuroscience (2017)
Calcium-Sensing Receptors
Goodman WG, et al.
Seminars in Nephrology, 24, 17-24 (2004)
Increased Calcium-Sensing Receptor Immunoreactivity in the Hippocampus of a Triple Transgenic Mouse Model of Alzheimer's Disease.
Emanuela G, et al.
Frontiers in Neuroscience, 2017 -2017 null
Genetic Risk Factors for Idiopathic Urolithiasis: A Systematic Review of the Literature and Causal Network Analysis.
Taguchi K, et al.
European eurology focus, 3, Taguchi K-Taguchi K (2017)
Effect of extracellular calcium on regucalcin expression and cell viability in neoplastic and non-neoplastic human prostate cells
Vaz CV, et al.
Biochimica et Biophysica Acta, 1853, 2621-2628 (2015)

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