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B8299

N-Butyldeoxynojirimycin

film (dried in situ), ≥98% (TLC)

Sinonimo/i:

Miglustat, NB-DNJ

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Cambia visualizzazione
Voi/SKUDisponibilitàPrezzo
1 mg
Per conoscere la disponibilità, visualizza il carrello
CHF 434.00
5 mg
Per conoscere la disponibilità, visualizza il carrello
CHF 1460.00

Informazioni su questo articolo

Formula empirica (notazione di Hill):
C10H21NO4
Numero CAS:
Peso molecolare:
219.28
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.32
MDL number:

CHF 434.00


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Nome del prodotto

N-Butyldeoxynojirimycin, film (dried in situ)

assay

≥98% (TLC)

Quality Segment

form

film (dried in situ)

solubility

water: 9.80-10.20 mg/mL, clear, colorless

storage temp.

2-8°C

SMILES string

CCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO

InChI

1S/C10H21NO4/c1-2-3-4-11-5-8(13)10(15)9(14)7(11)6-12/h7-10,12-15H,2-6H2,1H3/t7-,8+,9-,10-/m1/s1

InChI key

UQRORFVVSGFNRO-UTINFBMNSA-N

Gene Information

human ... UGCG(7357)

General description

N-Butyldeoxynojirimycin is an alkylated product of imino sugar deoxynojirimycin.

Application

N-Butyldeoxynojirimycin has been used:
  • in the inhibition of glycolipid synthesis in neuroblastoma cells
  • in the inhibition the ceramide-specific glycosyltransferase in hepatocytes
  • in the inhibition of β-glucosidase (GBA2) using fluorescence- activity assay in human embryonic kidney (HEK293) cells.

Biochem/physiol Actions

α-glucosidase Inhibitor
N-Butyldeoxynojirimycin is an inhibitor of glucosyltransferase and α-glucosidases. N-Butyldeoxynojirimycin, also known as misglustat, reduces glycolipid levels by substrate reduction therapy (SRT) and is effectively used for the treatment of glycosphingolipid lysosomal storage disorder, Gaucher disease.

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Questo articolo
N8638A5585D4268
description

film (dried in situ)

description

chitinase and lysozyme substrate

description

≥98% (TLC), powder

description

-

assay

≥98% (TLC)

assay

≥98% (TLC)

assay

≥98% (TLC)

assay

≥98% (TLC)

Gene Information

human ... UGCG(7357)

Gene Information

-

Gene Information

human ... SCNN1A(6337), SCNN1B(6338), SCNN1D(6339), SCNN1G(6340)
mouse ... Scnn1a(20276), Scnn1b(20277), Scnn1d(140501), Scnn1g(20278)
rat ... Scnn1a(25122), Scnn1b(24767), Scnn1g(24768)

Gene Information

human ... NOS1(4842), NOS2(4843), NOS2B(201288), NOS2C(645740), NOS3(4846)

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

form

film (dried in situ)

form

powder

form

powder

form

powder

solubility

water: 9.80-10.20 mg/mL, clear, colorless

solubility

DMSO: 9.80-10.20 mg/mL, clear to slightly hazy, colorless to yellow

solubility

methanol: 9.80-10.20 mg/mL, clear, pale yellow to yellow

solubility

water: 50 mg/mL, clear, colorless

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

room temp


Classe di stoccaggio

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)



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Questions

  1. How long is B8299 stable when dissolved in water, and at what temperature can I store it when it is in solution?

    1 answer
    1. The stability of this material in solution has not been investigated. However, other sources indicate that this compound is soluble in water at >35 mg/mL as well as in DMSO up to 65 mg/mL and Ethanol up to 22 mg/mL. Stock solutions may be stable for 1 month at -20°C and possibly 6 – 12 months at -80°C. Avoid repeated freeze/thaw cycles. This information has not been validated.

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