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A2380

Sigma-Aldrich

2-Aminopurine nitrate salt

≥99%

Sinonimo/i:

2-AP nitrate salt

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About This Item

Formula empirica (notazione di Hill):
C5H5N5 · HNO3
Numero CAS:
51-16-1
Peso molecolare:
198.14
Numero MDL:
MFCD00038989
Codice UNSPSC:
41106305
ID PubChem:
24890480
NACRES:
NA.51

Origine biologica

synthetic

Livello qualitativo

100

Saggio

≥99%

Forma fisica

powder

Solubilità

water: 50 mg/mL, clear, faintly to light yellow

Stringa SMILE

O[N+]([O-])=O.Nc1ncc2[nH]cnc2n1

InChI

1S/C5H5N5.HNO3/c6-5-7-1-3-4(10-5)9-2-8-3;2-1(3)4/h1-2H,(H3,6,7,8,9,10);(H,2,3,4)
PGDNOZBGABWZLD-UHFFFAOYSA-N

Applicazioni

2-Aminopurine (2-AP) is used to specifically inhibit double-stranded RNA-dependent protein kinase, protein kinase R (PKR).

Pittogrammi

Exclamation mark
GHS07

Avvertenze

Warning

Indicazioni di pericolo

H302

Classi di pericolo

Acute Tox. 4 Oral

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Gloves

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Yasumi Endoh et al.
Journal of immunology (Baltimore, Md. : 1950), 182(4), 2258-2268 (2009-02-10)
The S100 calcium-binding proteins S100A8 and S100A9 are elevated systemically in patients with viral infections. The S100A8-S100A9 complex facilitated viral replication in human CD4(+) T lymphocytes latently infected with HIV-1- and S100A8-induced HIV-1 transcriptional activity. Mechanisms inducing the S100 genes
Michael E Lindquist et al.
Virology, 413(1), 103-110 (2011-03-08)
We performed experiments to determine the effect of PKR activation on respiratory syncytial virus (RSV) replication. We first determined that RSV infection activates PKR which induces the phosphorylation of eIF2α, resulting in the formation of host stress granules. We used
Chen-Hsuan Wang et al.
Brain research bulletin, 79(3-4), 169-176 (2009-05-12)
Molecules involved in self-protection of neurons against glucose/oxygen/serum deprivation (GOSD) were investigated. Trypan blue dye exclusion assay, Western blotting, ELISA, cytokine antibody array and chemical blocking assay were applied in the study. Results showed that early induction (at 6h of
Junpei Teramachi et al.
Experimental cell research, 316(19), 3254-3262 (2010-08-24)
Double-stranded RNA-dependent protein kinase (PKR) plays a critical role in antiviral defence of the host cells. PKR is also involved in cell cycle progression, cell proliferation, cell differentiation, tumorigenesis, and apoptosis. We previously reported that PKR is required for differentiation
Renata M S Pereira et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 24(2), 617-626 (2009-10-09)
The evolution of Leishmania infection depends on the balance between microbicidal and suppressor macrophage functions. Double-stranded RNA (dsRNA)-activated protein kinase R (PKR), a classic antiviral protein, is able to regulate a number of signaling pathways and macrophage functions. We investigated
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