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Documenti fondamentali

A1887

Sigma-Aldrich

Albumina

lyophilized powder, essentially fatty acid free

Sinonimo/i:

HSA

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100 MG
CHF 58.70
500 MG
CHF 115.00
1 G
CHF 270.00
5 G
CHF 874.00
10 G
CHF 1’050.00
25 G
CHF 2’210.00

CHF 58.70


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Cambia visualizzazione
100 MG
CHF 58.70
500 MG
CHF 115.00
1 G
CHF 270.00
5 G
CHF 874.00
10 G
CHF 1’050.00
25 G
CHF 2’210.00

About This Item

Numero CAS:
Numero CE:
Numero MDL:
Codice UNSPSC:
12352202
eCl@ss:
42010201
NACRES:
NA.25

CHF 58.70


Spedizione prevista il01 giugno 2025


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Origine biologica

human

Livello qualitativo

Saggio

≥96% (agarose gel electrophoresis)

Stato

lyophilized powder

PM

monomer calculated mol wt 66478 Da

tecniche

ELISA: suitable
tissue culture: suitable
western blot: suitable

Impurezze

HIV I and HIVII, HCV and HBsAg, tested negative
≤0.007% Fatty Acids

Solubilità

H2O: soluble 50 mg/mL, clear to slightly hazy

N° accesso UniProt

Temperatura di conservazione

2-8°C

Stringa SMILE

FC(F)(F)C(F)(F)C(F)(F)F

InChI

1S/C3F8/c4-1(5,2(6,7)8)3(9,10)11
QYSGYZVSCZSLHT-UHFFFAOYSA-N

Informazioni sul gene

human ... ALB(213)

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Descrizione generale

Albumin is the most abundant plasma protein in human. It has a molecular weight of 66.5 kDa.[1]

Applicazioni

Albumin from human serum has been used:
  • as a carrier of CPT-11 (irinotecan, Campto) and SN-38 to investigate its binding to human plasma proteins[2]
  • to study the adsorption of water and acetonitrile (AN) vapor on a human serum albumin[3]
  • to study its effect on wound healing process[4]

Azioni biochim/fisiol

Le albumine sono proteine monomeriche solubili presenti nei fluidi e nei tessuti corporei degli animali e nei semi di alcune piante. L′albumina sierica svolge le funzioni di proteina carrier per gli steroidi, gli acidi grassi e gli ormoni tiroidei. Le albumine sieriche sono anche di vitale importanza nella regolazione delle pressioni colloido-osmotiche del sangue.
L′albumina sierica svolge le funzioni di proteina carrier per gli steroidi, gli acidi grassi e gli ormoni tiroidei ed è di vitale importanza nella regolazione delle pressioni colloido-osmotiche del sangue. È stato anche osservato che l′albumina si lega a sostanze esogene, farmaci in particolare (per es. ibuprofene, warfarin) influenzandone pesantemente la farmacocinetica. Lo stress ossidativo che determina modificazioni dello stato redox dell′albumina ha effetti molto variabili sulla sua funzione fisiologica.
Serum albumin primarily mediates divalent cation transportation, fatty acid and drug complex formation and transport.[5] The albumin levels in the serum indicate the disease progression in advanced liver disease.[1] Low body weight and decreased serum albumin is associated with colorectal cancer.[6]

Nota sulla preparazione

Prepared from albumin (A1653)

Altre note

Vedere maggiori informazioni sull′albumina sierica umana.

Esclusione di responsabilità

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves


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The journal of physical chemistry. B, 117(37), 10798-10806 (2013-09-06)
This work demonstrates for the first time that binding of various compounds within subdomain IB of human serum albumin (HSA) provokes characteristic changes in the near-UV circular dichroism (CD) spectrum of the protein. It can be inferred from the spectroscopic
S Miyata et al.
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Pyrraline is one of the major Maillard compounds resulting from the reaction of glucose with amino compounds at slightly acidic pH. For in vivo studies, monoclonal pyrraline antibodies were raised after immunization of Balb/c mice with keyhole limpet hemocyamin-caproyl pyrraline
A J Crowle et al.
Infection and immunity, 55(12), 2945-2950 (1987-12-01)
Historically, sunlight has seemed to fortify antituberculosis resistance. Evidence is presented here suggesting a role for vitamin D in this effect. The active metabolite of this photosynthesized vitamin, 1,25-dihydroxy-vitamin D3 (1,25D), promotes maturation and activation of human monocytes and macrophages
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Equilibrium dialysis, ultrafiltration, and ultracentrifugation were compared to determine their reliability and applicability in the study of binding of an anticonvulsant drug, valproic acid, by plasma proteins. We studied drug binding with pooled serum and with solutions of human serum

Questions

  1. What is the purpose of the charcoal purification step, and has it been verified that charcoal is not present in the final product? Additionally, how can it be ensured that components of the buffer used for lyophilization are not present in the final product if they are not tested for on the COA?

    1 answer
    1. The purpose of the charcoal purification step is to remove fatty acids from the albumin solution, and it has been verified that no traces of charcoal are present in the final product. As for ensuring that components of the buffer used for lyophilization are not present in the final product, it is currently considered salt-free, but there is potential to characterize it by ICP-MS.

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