A111000

DMT-dA(bz) Phosphoramidite

• Sinonimo/i: N6-Benzoyl-5′-O-(4,4′-dimethoxytrityl)-2′-deoxyadenosine-3′-O-[O-(2-cyanoethyl)-N,N′-diisopropylphosphoramidite]
• Formula empirica (notazione di Hill): C₄₇H₅₂N₇O₇P
• Numero CAS: 98796-53-3
• Peso molecolare: 857.93
• Numero MDL: MFCD00036314
• Codice UNSPSC: 41116107
• ID PubChem: 329770657
• NACRES: NA.51

Proprietà

• Origine biologica: non-animal source (no BSE/TSE risk)
• Livello qualitativo: 200
• Tipo: for DNA synthesis
• Nome Commerciale: Proligo Reagents
• Saggio: ≥99% (³¹P-NMR); ≥99.0% (reversed phase HPLC)
• Forma fisica: powder or granules
• tecniche: oligo synthesis: suitable
• Impurezze: ≤0.3 wt. % water content (Karl Fischer)
• Colore: white to off-white
• λ: conforms (UV/VIS Identity)
• Profilo del nucleoside: base: deoxyadenosine; base protecting group: benzoyl; 2' protecting group: none; 5' protecting group: DMT; deprotection: standard
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: COc1ccc(cc1)C(OC[C@H]2O[C@H](C[C@@H]2OP(OCCC#N)N(C(C)C)C(C)C)n3cnc4c(NC(=O)c5ccccc5)ncnc34)(c6ccccc6)c7ccc(OC)cc7
• InChI: 1S/C47H52N7O7P/c1-32(2)54(33(3)4)62(59-27-13-26-48)61-40-28-42(53-31-51-43-44(49-30-50-45(43)53)52-46(55)34-14-9-7-10-15-34)60-41(40)29-58-47(35-16-11-8-12-17-35,36-18-22-38(56-5)23-19-36)37-20-24-39(57-6)25-21-37/h7-12,14-25,30-33,40-42H,13,27-29H2,1-6H3,(H,49,50,52,55)/t40-,41+,42+,62?/m0/s1; GGDNKEQZFSTIMJ-AKWFTNRHSA-N

Descrizione

Descrizione generale

DMT-dA(bz) Phosphoramidite belongs to the group of DNA Phosphoramidites.

Its key features include:

• Exocyclic amine functions are protected by a benzoyl group (dA(bz) anddC(bz)) or isobutyryl group (dG(ib))
• Recommended cleavage and deprotection conditions are 8 hours at 55 °Cor 24 hours at room temperature using concentrated ammonia solution,for standard base-protected oligonucleotides
• The high coupling efficiency of Proligo′s DNA phosphoramidites leads tohigh-yield and high-quality oligonucleotides