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26430

Sigma-Aldrich

Chlortetracycline hydrochloride

BioReagent, suitable for fluorescence, from Streptomyces aureofaciens, ≥85.0% (HPLC)

Sinonimo/i:

7-Chlorotetracycline hydrochloride

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About This Item

Formula empirica (notazione di Hill):
C22H23ClN2O8 · HCl
Numero CAS:
64-72-2
Peso molecolare:
515.34
Beilstein:
3858364
Numero CE:
200-591-7
Numero MDL:
MFCD00082440
Codice UNSPSC:
51102829
ID PubChem:
57648175
NACRES:
NA.85
Prezzi e disponibilità al momento non sono disponibili

Origine biologica

Streptomyces aureofaciens

Nome Commerciale

BioReagent

Saggio

≥85.0% (HPLC)

Stato

powder or crystals

Colore

faintly yellow to yellow

Punto di fusione

210-215 °C (dec.) (lit.)

Solubilità

H2O: 50 mg/mL

Compatibilità

suitable for fluorescence

Spettro attività antibiotica

Gram-negative bacteria
Gram-positive bacteria

Modalità d’azione

protein synthesis | interferes

Temperatura di conservazione

−20°C

Stringa SMILE

Cl.CN(C)[C@H]1[C@@H]2CC3C(=C(O)[C@]2(O)C(=O)C(C(N)=O)=C1O)C(=O)c4c(O)ccc(Cl)c4[C@@]3(C)O

InChI

1S/C22H23ClN2O8.ClH/c1-21(32)7-6-8-15(25(2)3)17(28)13(20(24)31)19(30)22(8,33)18(29)11(7)16(27)12-10(26)5-4-9(23)14(12)21;/h4-5,7-8,15,26,28-29,32-33H,6H2,1-3H3,(H2,24,31);1H/t7?,8-,15-,21-,22-;/m0./s1
CBHYYLPALVVVEY-LYNLVHCPSA-N

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Categorie correlate

Descrizione generale

Chemical structure: tetracycline

Applicazioni

Cell-permeable fluorescent probe for Ca2+ for measuring calcium flux in endoplasmic reticulum and other intracellular stores in situ.

Azioni biochim/fisiol

Chlortetracycline is an antibiotic produced by some strains of Streptomyces aureofaciens.
Mode of Action: Inhibits protein synthesis (elongation) by preventing binding of aminoacyl-tRNA to the 30S subunit.
Antimicrobial spectrum: Gram-positive. Less active against Gram-negative bacteria than tetracycline.
Mode of Resistance: Loss of cell wall permeability.

Confezionamento

5 g, 25 g, 100g

Qualità

Recommended for fluorescent studies of calcium signaling in cells or tissues.

Altre note

Keep container tightly closed in a dry and well-ventilated place.

Pittogrammi

Health hazardExclamation mark
GHS08,GHS07

Avvertenze

Warning

Indicazioni di pericolo

H315,H317,H319,H335,H361fd

Classi di pericolo

Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

Organi bersaglio

Respiratory system

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Gloves

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Certificati d'analisi (COA)

Lot/Batch Number
0000434329
0000434329
0000412457
0000412457
0000363186

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Zhanna Hakhverdyan et al.
Molecular cell, 81(1), 153-165 (2020-12-18)
Cellular processes are largely carried out by macromolecular assemblies, most of which are dynamic, having components that are in constant flux. One such assembly is the nuclear pore complex (NPC), an ∼50 MDa assembly comprised of ∼30 different proteins called
Changlong Gou et al.
Bioresource technology, 323, 124517-124517 (2020-12-29)
Chlorotetracycline (CTC) is one of the most antibiotics present in cattle manure. In present study, three levels of CTC (0, 20 and 40 mg kg-1) were added to cattle manure composting systems to investigate its effects on the distribution of antibiotic-resistant genes
Kenneth N Agwuh et al.
The Journal of antimicrobial chemotherapy, 58(2), 256-265 (2006-07-04)
The pharmacokinetics of tetracyclines and glycylcyclines are described in three groups. Group 1, the oldest group, represented by tetracycline, oxytetracycline, chlortetracycline, demeclocycline, lymecycline, methacycline and rolitetracycline is characterized by poor absorption after food. Group 2, represented by doxycycline and minocycline
A E Oliver et al.
Biophysical journal, 78(4), 2116-2126 (2000-03-29)
The effect of temperature on the binding equilibria of calcium-sensing dyes has been extensively studied, but there are also important temperature-related changes in the photophysics of the dyes that have been largely ignored. We conducted a systematic study of thermal
Claudia Cerella et al.
Annals of the New York Academy of Sciences, 1099, 490-493 (2007-04-21)
Many studies suggest that endoplasmic reticulum (ER) Ca2+ pool rather than cytosolic Ca2+ may play a crucial role in triggering apoptosis. In this study, we performed an image analysis of cells loaded with the fluorescent dye chlortetracycline (CTC) to in
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