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258024

Sigma-Aldrich

(±)-α-tocoferolo

≥95.5%

Sinonimo/i:

DL-all-rac-α-tocoferolo, Vitamina E

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5 G
CHF 36.00
100 G
CHF 178.00
500 G
CHF 738.00

CHF 36.00

Spedizione prevista il06 aprile 2025

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Cambia visualizzazione
5 G
CHF 36.00
100 G
CHF 178.00
500 G
CHF 738.00

About This Item

Formula empirica (notazione di Hill):
C29H50O2
Numero CAS:
10191-41-0
Peso molecolare:
430.71
Beilstein:
94012
Numero CE:
233-466-0
Numero MDL:
MFCD00006848
Codice UNSPSC:
12352205
eCl@ss:
34058016
ID PubChem:
57648149
NACRES:
NA.28

CHF 36.00

Spedizione prevista il06 aprile 2025

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Origine biologica

synthetic

Livello qualitativo

200

Saggio

≥95.5%

Stato

liquid

tecniche

HPLC: suitable

Colore

faint brown to brown
 yellow to very dark yellow

Densità

0.950 g/mL at 20 °C (lit.)

applicazioni

cell analysis

Temperatura di conservazione

2-8°C

Stringa SMILE

CC(C)CCCC(C)CCCC(C)CCCC1(C)CCc2c(C)c(O)c(C)c(C)c2O1

InChI

1S/C29H50O2/c1-20(2)12-9-13-21(3)14-10-15-22(4)16-11-18-29(8)19-17-26-25(7)27(30)23(5)24(6)28(26)31-29/h20-22,30H,9-19H2,1-8H3
GVJHHUAWPYXKBD-UHFFFAOYSA-N

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Categorie correlate

Descrizione generale

α-Tocopherol is the active form of vitamin E.[1] It functions as an hydroperoxyl radical scavenger and protects the organism from oxidative damage. α-Tocopherol plays a crucial role in cell signalling and regulating immune responses.[2] α-Tocopherol deficiency is associated with abetalipoproteinemia, cystic fibrosis and celiac disease.[1] It has antiproliferative effects.[3] It inhibits arsenite-induced damage of human fibroblasts.[4]

Applicazioni

α-Tocopherol has been used:
  • as a standard to determine its concentration by reverse-phase high-performance liquid chromatography[5][6]
  • to study its rescue effects on chlorine dioxide (ClO2) cytotoxicity[7]
  • to assess its protective effects on acetaminophen (APAP)-mediated liver damage[8]

Azioni biochim/fisiol

Tocopherols (TCP) (vitamin E) are a series (α, β, γ and δ) of chiral organic molecules that vary in their degree of methylation of the phenol moiety of the chromanol ring. Tocopherols are lipid soluble anti-oxidants that protect cell membranes from oxidative damage. α-Tocopherol is the form of tocopherol preferentially absorbed by homo sapiens. Various isofroms and analogues of tocopherol have opposing and differentiated regulatory activities in vivo.

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08168

Timestrip Plus™ 8 °C

Pittogrammi

Exclamation mark
GHS07

Avvertenze

Warning

Indicazioni di pericolo

H317

Classi di pericolo

Skin Sens. 1

Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Dispositivi di protezione individuale

Eyeshields, Gloves

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Certificati d'analisi (COA)

Lot/Batch Number
0000311457
0000356109
0000356109
0000311457
MKCV0255

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(±)-α-tocoferolo Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1031

(±)-α-tocoferolo

(+)-γ-Tocopherol ≥96% (HPLC)

Sigma-Aldrich

T1782

(+)-γ-Tocopherol

Αlfa tocoferolo United States Pharmacopeia (USP) Reference Standard

USP

1667600

Αlfa tocoferolo

DL-α-Tocopherol acetate ≥96% (HPLC)

Sigma-Aldrich

T3376

DL-α-Tocopherol acetate

DL-alpha-Tocopherol acetate analytical standard

Supelco

47786

DL-alpha-Tocopherol acetate

δ-Tocopherol analytical standard

Supelco

47784

δ-Tocopherol

(±)-α-tocoferolo 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

Supelco

V-020

(±)-α-tocoferolo

(±)-α-tocoferolo dry powder, EMPROVE® ESSENTIAL, Ph. Eur., BP

SAFC

5.00878

(±)-α-tocoferolo

(+)-α-Tocopherol acetate BioReagent, suitable for insect cell culture, ~1360 IU/g

Sigma-Aldrich

T1157

(+)-α-Tocopherol acetate

(+)-γ-Tocopherol analytical standard

Supelco

47785

(+)-γ-Tocopherol

Effect of vitamin E on oxidative stress level in blood, synovial fluid, and synovial tissue in severe knee osteoarthritis: a randomized controlled study
Tantavisut S, et al.
BMC Musculoskelet. Disord., 18(1), 281-281 (2017)
Nutritional deficiencies and syndromes associated with alcoholism
Textbook of Clinical Neurology (Third Edition), 897-917 (2007)
Early Diagnosis and Treatment of Cancer Series: Prostate Cancer E-Book: Expert Consult - Online and Print, 897-917 (2015)
Oxidative stress induced by chlorine dioxide as an insecticidal factor to the Indian meal moth, Plodia interpunctella
Kumar S, et al
Pesticide Biochemistry and Physiology, 124, 48-59 (2015)
Glycosphingolipids Prevent APAP and HMG-CoA Reductase Inhibitors-mediated Liver Damage: A Novel Method for ?Safer Drug? Formulation that Prevents Drug-induced Liver Injury
Mizrahi M, et al.
Journal of clinical and translational hepatology, 6(2), 1-8 (2018)
Visualizza tutti i documenti correlati

Articoli

Dietary Antioxidants

Antioxidants protect biological systems from oxidative damage produced by oxygen-containing free radicals and from redoxactive transition metal ions such as iron, copper, and cadmium.

Questions

1–3 of 3 Questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  3. Could you please provide the concentration of this product (mg/ml)?

    1 answer

    1. This product is a neat or pure liquid and has not been diluted. This material has a density of 0.950 g/mL and a molecular weight of 430.71 g/mol. The minimum purity is 95.5%, thus the molarity will vary slightly from lot to lot. The molarity can range from 2.11M (95.5%) to 2.20M (100%).

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