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Merck
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Documenti

21279

Sigma-Aldrich

Calyculin A from Discodermia calyx

≥90% (HPLC)

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About This Item

Formula empirica (notazione di Hill):
C50H81N4O15P
Numero CAS:
101932-71-2
Peso molecolare:
1009.17
Beilstein:
4903216
Numero MDL:
MFCD06795864
Codice UNSPSC:
12352200
ID PubChem:
329752128
NACRES:
NA.77

Saggio

≥90% (HPLC)

Forma fisica

solid

Temperatura di conservazione

−20°C

Stringa SMILE

COC[C@@H]([C@H](O)[C@H](O)C(=O)NCC[C@H](C)c1nc(\C=C\C[C@@H]2O[C@]3(C[C@@H](O)[C@@H]2C)OC([C@H](C[C@H](O)[C@H](C)[C@H](O)[C@H](C)\C=C(C)\C(C)=C\C=C\C(C)=C/C#N)OC)[C@H](OP(O)(O)=O)C3(C)C)co1)N(C)C

InChI

1S/C50H81N4O15P/c1-29(20-22-51)16-14-17-30(2)32(4)24-33(5)42(57)35(7)38(55)25-41(65-13)45-46(69-70(61,62)63)49(8,9)50(68-45)26-39(56)34(6)40(67-50)19-15-18-36-27-66-48(53-36)31(3)21-23-52-47(60)44(59)43(58)37(28-64-12)54(10)11/h14-18,20,24,27,31,33-35,37-46,55-59H,19,21,23,25-26,28H2,1-13H3,(H,52,60)(H2,61,62,63)/b16-14+,18-15+,29-20-,30-17+,32-24+/t31-,33+,34-,35-,37-,38-,39+,40-,41-,42+,43-,44-,45+,46-,50+/m0/s1
FKAWLXNLHHIHLA-YCBIHMBMSA-N

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Azioni biochim/fisiol

Inhibitor of protein phosphatases types 1 and 2A; marine toxin, potent tumor promotor.

Altre note

Potent inhibitor of protein phosphatases 1 and 2A. More than 10 times more effective for PP1 than okadaic acid

Pittogrammi

Skull and crossbones
GHS06

Avvertenze

Danger

Indicazioni di pericolo

H301 + H311 + H331,H315

Classi di pericolo

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Skin Irrit. 2

Codice della classe di stoccaggio

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Certificati d'analisi (COA)

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L.C. Starke et al.
The American Journal of Physiology, 264 (1993)
Michael A Kuefner et al.
International journal of radiation biology, 89(6), 424-432 (2013-02-01)
The purpose of this study was to investigate the effect of calyculin A on the number of γ-H2AX foci (phosphorylated histone variant 2AX) in lymphocytes after in vitro and in vivo irradiation with rather low doses as they are used
Koji Ashizawa et al.
Theriogenology, 79(3), 558-565 (2012-12-19)
Potential mechanisms of the reversible temperature-dependent immobilization of fowl sperm were investigated. At 30 °C, motility of demembranated fowl sperm was inhibited by adding 2 mM ethylene glycol-bis (2-aminoethylether)-N,N,N',N'-tetraacetic acid (EGTA), but restored immediately after the subsequent addition of 2
Carlos Zgheib et al.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, 32(2), 87-94 (2011-12-07)
Vascular inflammation is initiated by stimuli acting on endothelial cells. A clinical feature of vascular inflammation is increased circulating interleukin 6 (IL-6) type cytokines such as leukemia inhibitory factor (LIF), but their role in vascular inflammation is not fully defined.
Haruhiko Miyata et al.
Cytoskeleton (Hoboken, N.J.), 69(4), 207-220 (2012-01-27)
Many motile processes are regulated such that movement occurs only upon activation of a signaling cascade. Sperm from a variety of species are initially quiescent and must be activated prior to beating. The signaling events leading to the activation and
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