Based on the information available, this version does recognize the epsilon subunit. This conclusion is drawn from the fact that the CD3 epsilon, also known as the cytoplasmic CD3 antibody, exhibits a cytoplasmic staining pattern with perinuclear Golgi accentuation and very rarely membranous. Typically, this antibody is utilized for identifying T cell and NK cell lymphomas in FFPE tissues (please refer to representative staining photos). While the Cd3 surface antibody is commonly used in flow cytometry for membranous CD3 detection, the CD3 epsilon cytoplasmic is generally used in FFPE tissue, as is often done for IHC.
103R-9
CD3 (MRQ-39) Rabbit Monoclonal Antibody
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About This Item
Codice UNSPSC:
12352203
NACRES:
NA.41
Prezzi e disponibilità al momento non sono disponibili
Prodotti consigliati
Origine biologica
rabbit
Livello qualitativo
100
500
Coniugato
unconjugated
Forma dell’anticorpo
culture supernatant
Tipo di anticorpo
primary antibodies
Clone
MRQ-39, monoclonal
Descrizione
For In Vitro Diagnostic Use in Select Regions (See Chart)
Stato
buffered aqueous solution
Reattività contro le specie
human
Confezionamento
pkg of 0.1 mL concentrate (103r-94)
pkg of 0.5 mL concentrate (103R-95)
pkg of 1.0 mL concentrate (103R-96)
pkg of 1.0 mL predilute (103R-97)
pkg of 7.0 mL predilute (103R-98)
Produttore/marchio commerciale
Cell Marque®
IVD
for in vitro diagnostic use
tecniche
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500 (concentrated)
Isotipo
IgG1
Controllo
tonsil
Condizioni di spedizione
wet ice
Temperatura di conservazione
2-8°C
Visualizzazione
membranous
Informazioni sul gene
human ... CD3E(916)
Categorie correlate
Descrizione generale
Anti-CD3 has been considered the best all around T-cell marker. This antibody reacts with an antigen present in early thymocytes. The positive staining of this marker may represent a sign of early commitment to the T-Cell lineage.
Qualità
 IVD |  IVD |  IVD |  RUO |
Linkage
CD3 Positive Control Slides, Product No. 103S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
Stato fisico
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide
Nota sulla preparazione
Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.
Altre note
For Technical Service please contact: 800-665-7284 or email: [email protected]
Note legali
Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany
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SM Denning, et al.
Leucocyte Typing III, 144-147 (1987)
E A Clark et al.
Immunology today, 10(7), 225-228 (1989-07-01)
During 1987, striking advances were made in defining the receptors and ligands for cell-to-cell adhesion interactions involving leukocytes. In 1988, two major leukocyte differentiation antigens, CD10 (cALLA) and CD45 (LCA, T200), were shown to be enzymes while two other markers
P C Beverley et al.
European journal of immunology, 11(4), 329-334 (1981-04-01)
The properties of human lymphocyte fractions isolated either by sheep red cell(E) rosetting or by fluorescence-activated cell sorting after staining with UCHT1 monoclonal anti-T cell antibody have been compared. Two populations of E+ cells with very different phenotype and function
D Campana et al.
Journal of immunology (Baltimore, Md. : 1950), 138(2), 648-655 (1987-01-15)
Anti-CD3 (T3) Ab reacting with different proportions of thymocytes (anti-CD3a: UCHT1, anti-CD3b: T10B9, and anti-CD3c: OKT3) were tested for cytoplasmic (cCD3) and membrane (mCD3) expression in the bone marrow, thymus, and blood in man and selected primates. The expression of
Kennosuke Karube et al.
The American journal of surgical pathology, 27(10), 1366-1374 (2003-09-26)
We studied the morphologic, immunohistochemical, and clinical characteristics of 158 cases of lymphoblastic lymphoma. Based on immunophenotyping and cell lineage, cases were classified into B-cell type (CD20,CD19 or CD79a+, n = 53), T-cell type (surface CD3+, n = 84), and
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Could you confirm if the CD3 clone (Catalog #103R-96) recognizes epsilon?
1 answer-
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