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75047

Supelco

Piperine

analytical standard

Sinonimo/i:

1-Piperoylpiperidine

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About This Item

Formula empirica (notazione di Hill):
C17H19NO3
Numero CAS:
Peso molecolare:
285.34
Beilstein:
90741
Numero CE:
Numero MDL:
Codice UNSPSC:
85151701
ID PubChem:
NACRES:
NA.24

Grado

analytical standard

Livello qualitativo

Saggio

≥97.0% (HPLC)

Durata

limited shelf life, expiry date on the label

tecniche

HPLC: suitable
gas chromatography (GC): suitable

Punto di fusione

131-135 °C (lit.)

applicazioni

cleaning products
cosmetics
flavors and fragrances
food and beverages
personal care

Formato

neat

Temperatura di conservazione

2-8°C

Stringa SMILE

O=C(\C=C\C=C\c1ccc2OCOc2c1)N3CCCCC3

InChI

1S/C17H19NO3/c19-17(18-10-4-1-5-11-18)7-3-2-6-14-8-9-15-16(12-14)21-13-20-15/h2-3,6-9,12H,1,4-5,10-11,13H2/b6-2+,7-3+
MXXWOMGUGJBKIW-YPCIICBESA-N

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Descrizione generale

Piperine is a naturally occurring bioactive alkaloid in pepper, which imparts pungency and bitter flavor to it. It has demonstrated health benefits and exhibits therapeutic properties, which include its role as an antimicrobial, antioxidant, antifungal, immunomodulatory and hepatoprotective agent. The inhibition of drug-metabolizing enzymes in hepatic and pulmonary tissues, and the enhancement of drug bioavailability by this compound are reported. It is also found to play an important role in reducing blood glucose, cholesterol and triglycerides.
Piperine is an amide isolated from the plant, Piper longum. It is a known inhibitor of hepatic and intestinal glucuronidation. Piperine is found to exhibit pharmacological properties like antitumor, antipyretic and anti-inflammatory activities.

Applicazioni

Piperine may be used as an analytical reference standard for the quantification of the analyte in:
  • Human plasma using high-performance liquid chromatography coupled to electrospray ionization tandem mass spectrometry (HPLC-ESI-MS/MS).
  • Piper nigrum extract using reversed phase high pressure liquid chromatographic method with UV detection (RP-HPLC-UV).
  • Food products using high-performance liquid chromatography with diode array detection (HPLC-DAD).

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Pittogrammi

Exclamation markEnvironment

Avvertenze

Warning

Indicazioni di pericolo

Classi di pericolo

Acute Tox. 4 Oral - Aquatic Chronic 2

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable


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A liquid chromatography method for the simultaneous determination of curcumin and piperine in food products using diode array detection
Nagappan VK , et al.
Asian Journal of Research in Chemistry, 2(2), 115-118 (2009)
Preliminary study on inhibition of genotoxicity by piperine in mice
Selvendiran K, et al.
Fitoterapia, 76(3-4), 296-300 (2005)
Validated HPLC?MS/MS method for simultaneous determination of curcumin and piperine in human plasma
Wang M-X, et al.
Tropical Journal of Pharmaceutical Research, 11(4), 621-629 (2012)
Development and validation of rapid RP-HPLC method for estimation of piperine in Piper nigrum L
Upadhyay V, et al.
International Journal of Herbal Medicine, 1, 6-9 (2013)
Immunomodulatory and antitumor activity of Piper longum Linn. and piperine
Sunila.S.E and Kuttan.G
Journal of Ethnopharmacology, 90(2), 339- 346 (2004)

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